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Orianna - Suck my ball
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That is because of her ability to use extended attacks by making use of her ball, while she is staying behind her creep wave which, can ensure her a better and safer laning phase.
Because of that ability, she sounds easy to play and SEEMS easy to play to the enemies when they get dominated calling her OP and stuff like that.
The thing is that Orianna is actually hard to play just for one thing.
Since the beggining of the game, you have your ball over your head, which means when you cast your Command: Attack(Q), the ball will go straight towards the destination it was sent.It becomes much more tricky when the balls isn't on top of you, and it's laying down on the ground on a specific spot. When this is happening, if you cast your Command: Attack (Q), the ball will go to it's destination according to it's current location, which means you can easily miscalculate it's direction and angle, and lose a kill or cost you a death.
Now, the Magic Penetraion Marks are a classic AP rune for all kinds of heroes but it's helpful indeed.
Since you buy Mana Crystal in the beggining, you will not have a problem with your mana pool, so the Mana Regen Seals will help you keep your mana pool from being depleted.
My last item is Wit's End. To be honest, I once made it just for fun, because I thinked of my passive, which deals extra magic damage with each hit on the same target, and i thought that I needed to finish my build with a defensive item.
I thought of Wit's End because it gives you extra attack speed, which can help you stack your passive on your target much faster, the extra magic damage that it gives, combined to MY passive AND finnaly the magic ressistance it gives you to help you last longer against AP carries such as Brand, Veigar etc.
I recommend you guys to always build a defensive item as your last item, because with the rest of your build you get around 3K hp so it can make you last easily in teamfights, if you don't wanna make Wit's End it's ok, just buy yourself a defensive item just as Guardian Angel etc.
-Able to farm well in a safe distance
-Very good harrasment without taking damage
-Can use her ball as a ward to look inside the bushes for possible enemy ganks
-Very fragile early on
-Can be easily harmed when her spells are on cooldown (see her spell casting frequency early on and try to calculate it)