The city-state of Zaun is a twisted realm of science, mercantilism, and magic run amok. While the young science of techmaturgy does much to advance civilization, its research and use in Zaun pushes the boundaries of morality on a daily basis. Zaun, choked with pollution from the countless factories and laboratories that spew waste into the environment, suffers greatly. As polluted as Zaun is above-ground, its subterranean levels are far worse. All of Zaun's runoff waste pooled together in its sewers, mixing into a toxic and mysterious concoction. A single plague rat rose from this alchemical nightmare - Twitch. Unlike his lesser evolved cousins, Twitch became as sentient as anyone else... provided they were as insane as he. A seeming byproduct of the evolutionary brew that spawned him was maniacal insanity, albeit in a functional form.

Twitch came to the League of Legends to represent himself ''as the only one of his kind'' on the Fields of Justice. Since then, he has found a generous benefactor in the city that gave him his evolutionary sentience - Zaun. Twitch is one of Zaun's premier champions in the League, and as such he fights for Zaun when political disputes between Valoran's city-states arise. Twitch has publically stated that his goal is to gain enough influence and materiel from his work in the League to try to recreate the process by which he gained his sentience. While many challenges lie ahead in his quest - one of the largest being his own insanity - were he to succeed, it would mean a bold and brazen step forward in the evolution of all of Runeterra. Zaun has pledged its support for Twitch in his quest, though it remains to be seen what Zaun's ulterior motives are in the matter.

''The existence of Twitch proves that anything is possible on Runeterra.''
-- Heimerdinger

Hello if your reading this guide your probably looking for an effective way to play twitch i have used this build and it works great feel free to modify it to make it your own build because honestly the best build you can have is one you yourself invented i made this as my own from reading other guides without really liking the whole guide im not saying you have to make your own it would just be better to though (so it matches your play style) well more about twitch

For runes i like to go armor pen for red and quintessences armor and magic resist for yellow and blue they both help you do good early game for extra damage reduction where you will also be doing very good damage early game if you get enough poison stacks on them it will **** them up feel free to make yellow health or dodge i think armor works better than dodge because its much more reliable on twitch because dodge varies way to much health i never really tried seems like it would work good attack speed would work nice on twitch for blue but i doubt you would do better against mages well thats pretty much it for runes

I run a 21/0/9 which is pretty standard for twitch honestly you can do what ever as long as you have at least 9 in utility but i feel that this is the most effective for twitch

Early Game- OK what you wanna do early game is try and get first blood obviously if you don't have a full rune book don't be so aggressive try and play safer but if you do have one you wanna stealth behind your enemy and start shooting and don't do this if there's to many minions around him unless you have your own but your goal is to get a bunch of poison stacks on them.(note this only applys to mid you should figureout ur gonna lose to some people)
When you get your boots its time to start ganking you will need common sense to be successful work with your teammates

Mid Game- Never initiate the team fights and stay the hell away from people with oracles and be cautious of vision wards when there's team fights use your ult and try to line it up if possible normally it goes good if you let him auto attack but if you can try to and aim for squishes

Late Game- You probably have your infinity edge by now with your ult you should kill there team if you aren't getting focused oh and by the way let the team fight start before you pop out of stealth to reduce the chances of getting focused if you have all your items you can back door towers really good with your final and your ghost blades activate you can kill one without dieing but after you kill one heal on there minions and stealth away

I always start with this because it gives you everything you need very start good early damage a little bit of lifesteal and some health just all around good item for Twitch at the start.
These in my opinion are the best boots for twitch because makes getting back to your lane after ganking a hell of a lot easier you could go with berserker grieves if you don't really like leaving your lane to gank.
Best item ever for twitch makes him crit so damn high because for any ad carry the way to have the highest damage output is to have crit strikes and infinty edge makes him crit around 502 when he has this boots a zeal and a dorans blade.
This with the infinity edge makes your damage output extremely high more crit atkspeed and movement speed with this and the infinity edge your ult with those two items can kill a whole team.
This on twitch is badass because it adds more armor reduction/pen more attack speed and good damage when you get this it greatly increases your damage output honestly just a good item choice for him because he already has good attack speed so why not get some on hit effects.
Every ad champion needs at least one lifesteal item i used to get starks fever but i realized the aura gave me away when they would spam skill shots when i was near them stealthed was kinda funny though.
Great item for twitch more armor pen some more damage and cool down reduction its great if you remember to use your activate you can actually kill a tower alone if you use the activate.

Very useful summoner spell its awesome for getting away if your being focused or if you need to get the stealth timer off to get away.
I just straight love exhaust because it makes those early kills all the easier with this in the very start i normally get first blood or make them have to recall right away.

YOU MUST MUST MUST GANK Twitch is only a good champion if you play him effective making full

use of his stealth by ganking if you dont gank your a bad twitch thats why you get boots of

mobility instead of berserker greaves

Now this is a very important part of the guide because this is twitches main weakness and this is how i counter his weakness when there is a vision ward early game what i do is i put a vision ward by there's and kill don't get oracles to early it will slow down your build tremendously when there is a champion with an oracles i just ask my team to help me gank them or ill just focus them in team fights (yes even tanks)with twitches ult you can do that and with his armor reduction/pen you should do good damage to them and when the enemy team has oracles don't scout as much it will get you killed when you run in a bush and there there unless its only 1 but you would still be in danger

Twitch is a fun character and pissing the enemy team off by ganking them and then you see them come back with oracles is pretty funny but some of the strategies i do are if there low on a tower recalling use your ult for long range to finish them off and when you get your poison stacks on them try to keep your poison on them as long as possible before you expunge because i have seen people get away from me with below 50 life and it annoys me and when you play twitch watch your stealth buff closely it sometimes will run out unexpectedly and in the wrong place and time it will get you killed and don't be afraid to take on more than one if there low your ult will make it easy.

yes i added another build i use on twitch that one is the build i am currently using the other one works fine but your a glass cannon and i realized i dont need black cleaver considering there normally dead before those 3 stacks are gonna matter the frozen mallet is optional you can get a banshees for a heavy ap team or a black cleaver for a real squishy team all of them work great so dosent really matter to much

To sum it all up just play smart if you follow this guide you should be fine try it exactly like i do for the 1st time and make modifications after you see what you like and don't like and if you liked this guide please vote it up if you dont like it feel free to vote it down but please explain why thank you xD.