Tryndamere needs damage, damage and more damage. So i take all the Damage runes that are possible. Dmg/lvl gives the most late game, but you can take just plain damage if you want to be better early game.

For Tryndamere i take 25/5/0 because he needs damage. It gives him Damage, Crit chance and some Life steal, which is everything Trynda needs to

KICK SOME ***.

For Summoner Spells I take

Flash

and

Ignite

to increase my damage and to escape if necessary. Ignite will also reduce the healing of a Champion, so it's very usefull against champions like Vladimir , Dr.Mundo and Warwick.

Other options:

Exhaust

Exhaust is good to reduce the damage dealt of a champion and slow them. I don't take it because I use Mocking Shout for this, but you can feel free to choose it.

Ghost

If you prefer it to Flash then pick it.

Cleanse

Cleanse helps you to break out of CC.

Not recommended:

Heal

You can heal yourself with Bloodlust so why would you like to pick heal? There are some Spells that are more useful.

Clairvoyance

You should leave it to your supporter.

Clarity

Well :D I don't think I have to say something about it.

Passive

Tryndamere gains fury for every attack, critical strike or minion kill he does. He gains .35% critical strike chance for every point of fury (maximum 35%)

This passive is very strong. It increases Tryndamere's damage along the whole game. You should always try to have the full 100 fury.

Q-Skill

Passive: Tryndamere gains additional Attack Damage and some attack damage based on the health he's missing
Active: Tryndamere consumes his fury to give him some health back + some health based on the fury he used.

This skill helps Tryndamere to stay alive. The heal consumes all your fury so you should just use it when your about to die. The passive of this skill helps Tryndamere to deal more damage in the early game. I max Bloodlust first, so I have the most damage in the laning phase and can heal me, if I'm in trouble.

W-Skill

Tryndamere reduces the attack damage of all enemy champion near him. He also slows enemies that are not facing him.
Mocking Shout can have 2 good uses. 1 you can use it to chase a champion. Slow him when he's running away and kill him. Secondly you can use the Skill to reduce the attack damage of enemies in team fights or in a 1 vs 1. An enemy AD Carry with reduced attack damage is easier to kill and deals less damage. So Mocking Shout can turn a team fight with a strong enemy AD Carry into a win.

E-Skill

Tryndamere spins into a target area an damages all enemies he pass** through. Every critical strike Tryndamere does, will reduce the cooldown.

This skill is good for minion farming, escaping and chasing. With enough AD you can kill a whole minion wave with Spinning Slash. When you get ganked, just escape over a wall and when you are chasing someone, you can easily kill him with a Mocking Shout and Spinning Slash combo.

When you have enough damage and lifesteal, you can even use Spinning Slash to ''heal'' yourself in a mid lane team fight. Just spin to the ghosts, kill them and spin back into the fight. Spinning Slash should be back of it's cooldown, because of some critical strikes at the ghosts.

Ultimate

Tryndamere gains 50/75/100 fury and his hp can't fall under 1 for 5 seconds.
One of my favorite ulti's. Tryndamere can't die and the passive damage ammount of Bloodlust is as high as possible while Tryndamere has just 1 HP. Always make sure to hit ''R'' when your're about to die and

NOT

when you started to get damaged. A good timed ultimate of Tryndamere can change a dead into a doublekill or even more ;)

Note:

Bloodlust should be avaible after the duration of your Undying Rage, otherwise Ignite or champions like Teemo , Cassiopeia or Malzahar can easily kill you with their DoT.

Farm minions. Buy Attack speed, Damage and Life Steal. And...

KICK SOME ***

Basically, Trynda is one of the most

OP

Champions for any team. With a really good Ult, and a heal.