hello, before i start to write i am sorry for my poor english. So this is my 1st guide i am playing twitch really long time and i was try alot of builds to know twitch is really so much squishy but with good item choice he can be really good carry in every game.This is just my option of playing twitch.

ok for runes i choice : armor pen marks for better dmg
hp/per lvl seals to make you not so much squishy
armor pen quintessence for make more dmg
and for glyphs mana per lvl // atack speed(just your option to select
i am more up for attack speed for better early game)

ok for masteries 21/9/0 9 in defense for lesser squishy:) (just one point in brute force? ofc your start dmg with blade ll be 66per hit + poison that make 81 dmg per one shot sou better to gve those 2 points to defense)

ok why i go for 2 executioners?? alot of guides here just tell you build phantom dancer or infinity edge for 1st items problem of twitch is hes one of 1st targets in every game so i buy after boots 2 executioner it gives me great crit chance great lifesteal and thats ares stats which twitch need ofr start game when you have 2 executioners your ambush will be really efective nd you can start gank, with these items is easy to build phantom dancer and after infinity edge by myself i think better to buy phantom b4 infinity cause youll have great Attack speed and over 60% crit chance with these stats simple to farm for infinity and in few mins selllin dorans blade and change him for another infinity and after selll executioner and buy bloodthirster but its just by game for me when i got infinity a have around 10-15 kills and game is nearly end:)

Flash+ignite ignite is great spell for twitch and for my build is it necessar to have it cause just thx to him youll be owning from start to end :)

ok write me what you want to know more comment and vote :) have fu :)