Vayne is a ranged ad carry with 3 steroids. Her Q,W, and her ult. She has the most steroids in the game which makes here very strong as the game progresses. If you play this hero like she is meant to be played she can carry you to victory.

The reason why I picked these runes are because they are the standard rune build for an AD carry. Flat AD Runes for last hitting and helps with her other abilities. Flat Yellow Armor Runes for surviving lane. Flat Blue Magic Resistance for surviving lane. Flat Purple AD Quints for last hitting and damage on abilities.

21 offensive standard for any attack damage carry. 9 in defense for surviving laning phase.

The entire game what your goal is to get as much straight damage as possible. So what I do is I build Bloodthirster first for straight forwards damage. Then a zeal for a little attack speed and crit. Then I build a Last Whisper before my Phantom Dancer so the other team can't stack armor to counter me in teamfights. Then I build my Phantom Dancer for my main attack speed item. Then I build a survive ability such as Quick Silver Sash Or Guardian Angle. It really depends on what you are going against in your game. If you a going against a very high burst team get Guardian Angle. If you are going against a high CC team get a Quick Silver Sash. Then an Infinity Edge to top it all off. If the game goes on and you have no space left you can sell your boots for another Phantom Dancer.

Get heal if they have a very fast damage team. Get Cleanse if they have a very CC heavy team.

Pros: High Damage, Good Mobility, Invisibility, Can't really be built to countered.
Cons: Sucky laning phase, short range for an AD Carry.
Heroes that country Vayne in lane: Sivir, Cait, and Sona.

Always have yourself set behind your teammates never get caught or get cocky. Remember to kite since you have a very fast champion. Always make sure you get away from the bruiser trying to kill you or zone you. Always stay next to your team.

Make Sure you try to hit every CS in lane or you will have a very hard time late game. If the other ad carry is zoning you just farm under tower and hold the lane close to the tower so they can't zone you. If you don't farm you can't hyper carry like she is meant to. Farming is the most important part of being an AD carry.