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The nature of Zed's abilities makes him hard to handle, however, rushing Zhonya's Hourglass with massively impact the game and make your life much easier. Save Zhonya's for his ult.
Malzahar
Malzahar's Passive can get pretty annoying when you are trying to perform your burst or cage him, and sometimes they build Banshee's Veil which adds on to the annoyance, to to poke with your Q to remove his passive and watch out for him using flash ults. It's best to build Banshee's Veil yourself to counter him.
Fizz
Try to bait Fizz's E so you can perform your burst, Fizz can place your Ultimate on Cooldown if you use it during his E.
Katarina
Katarina is a pain, she can burst you down sometimes so quickly that it can give you wipe-lash. With Katarina's Q's you will notice daggers on the ground... she can jump to them and then ult you, try to land the edge of your cage on the dagger just as she jumps so you can get a free stun on her so you can perform your burst combo (W + Q + R | In that order)
Annie
Using your Cage makes and easy target for Annie to use her burst combo
Yuumi
Being completely honest, Yuumi Synergies with almost every champion fairly well, but with her W passive you share a percentage of each others AP, supercharging each other for strong damage.
Xayah
Allow Xayah to use her E to root them to the ground, then angle your cage to get the perfect stun, extending the duration of the immobility for an easy kill.
Ashe
Ashe's ult and slows make it extremely easy for you to land your burst combo, when she ults... cage them for that extra kill potential or vice versa
Blitzcrank
This is mainly for those trolling on the bot lane, If you land your cage around Blitz as he is pulling someone in, during the moment the enemy champion passes the cage that become stunned and allows both of you to do your instakill combo.
Synergies
IdealStrongOkLowNone
Annie
Using your Cage makes and easy target for Annie to use her burst combo
Yuumi
Being completely honest, Yuumi Synergies with almost every champion fairly well, but with her W passive you share a percentage of each others AP, supercharging each other for strong damage.
Xayah
Allow Xayah to use her E to root them to the ground, then angle your cage to get the perfect stun, extending the duration of the immobility for an easy kill.
Ashe
Ashe's ult and slows make it extremely easy for you to land your burst combo, when she ults... cage them for that extra kill potential or vice versa
Blitzcrank
This is mainly for those trolling on the bot lane, If you land your cage around Blitz as he is pulling someone in, during the moment the enemy champion passes the cage that become stunned and allows both of you to do your instakill combo.
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