1.You must always prefer mid for vladimir because it will helps u to gather money fast

2.Play defensive up to take sorcerer's shoes .if u take that u will have about 100 abitity power and 27 magic penetration


3.You will do quite damage to your opponet especially if he is squizi.

4.When u take ulti and all your item make first (on opponet) hemoplague then transfusion and sanguine pool if he has a little life try make tansfusion or tides of blood.

here are the item u must buy:
first take an amplyfying tome u will have quite ability power to slain many enemies at the start .if u feeded u would take fast all items.2nd take hextech relover.You will have 40 ability and 15% spell vamp.after that take sorcerer's shoes for magic penetration or ionian boots of lucidity for 15% cooldown.After take will of ancients.Only these items needs to play perfect with vladimir.Now you will have about 100 ability,27 magic penetration(with runes)and 20% spell vamp.After buy these items buy everything else u want but personaly the items i have put to build are better because i have 474 ability 20% spell vamp and 94 magic penetration.

Best runes for vladimir are
Greater Quintessence of Insight:These runes give you magic penetration and it's very helpfull for all the match.
Greater Mark of Insight:These runes give you magic penetration and it's very helpfull for all the match,too.
Greater Seal of Potency:These runes give you ability power and it's very helpfull for the start of the match only
Greater Glyph of Potency:These runes give you ability power and it's very helpfull for the start of the match only,too
NOW IF YOU WANT TO TAKE OLNY MAGIC PENETRATION YOU WILL HAVE A GREAT CHOISE

BUT IF YOU TAKE ONLY ABILITY POWER YOU MUST KNOW THAT IT HELPS FOR THE START OF THE MATCH ONLY

1. Transfusion:
Sucks enemy health and heals you! Your main move, Should be leveled to full ASAP. It has absolutely no cost so cast it every chance you get. Early game, Dip in, Cast it, and get out. Rinse Repeat till you have the advantage. Ignite the enemy and finish them off with Ghost+Sanguine Pool as they run away.
2. Sanguine Pool:
Turns you into a puddle of blood, Dealing damage to enemies above you as well as healing yourself. Cost 20% Current health to activate so use wisely! This move can be used for both Tower Diving and Escaping Ganks. Best used say if a nasty projectile is flying towards your face, pop it and dodge the move entirely and sneak away unharmed. Ex: Ashe's Ult, Sion's Stun, Blitz's Fist. Use it in conjunction with Ghost for an easy behind turret kill or to escape a neardeath gank. (DOES NOT STOP ENVIRONMENTAL STUNS! EX: Veigar's stun). Anyways! It should be the next skill you level up after Transfusion.
3. Tides of Blood:
This move can be extremely powerful during teamfights but deadly to yourself early game. I chose to only put one rank in it early game for minion farming and maybe a little boosted damage during a fight but nothing more. Towards the end, when you become entrenched in team fights this move will begin to shine.. When mixed with Sanguine Pool and Hemoplague you will begin to do some REALLY NASTY AoE damage. The trick is to just watch yourself and only cast it when you have the health to waste.
4. Hemoplague:
Your Ultimate, It has a long cooldown and I kind of skimped on CD reduction in the item builds! So pay attention and use it only when you can get the most out of it, Ex: 2 Champs early game, 3-4 Late Game in team fights. Preferably all five! Toss it on and follow it up with some Tides of Blood and watch the enemies' healths melt away. It works well with Ignite to provide a really nasty 600+ damage finisher. Level it every chance you get, It is your big daddy and can easily break the other team during a team fight.

SUMMONER SPELL YOU CAN TAKEFlash:you can take flash if you want to have certain kills because you can appear behind them and it's difficult to escape from a vladimir :).Telaport:take this spell only when you are going to play solo(if 1 of your allies is jungle or he is afk).Ignite:take this summoren spell if you want to do it when your enemy has a little lifeGhost:personally take this spell to chase your enemies who are trying to escape.Exhaust:personally take this spell for the same reason like ghost.Clairvyonance:it's 50% 50% to take this spell.Take it if you need to see the enemy when he is a little away.
SUMMONER SPELLS YOU MUST NEVER TAKE!
Heal:you don't need to take this spell because you can steal life with transfusion or with others spells(if you have spell vamp)Clarity:vladimir hasn't mana so he doesn't need clarity O.oFortify:vladimir says no!Revive:why take this summoner spell?If you do this you won't go at the right time the enemy was with a little life.also it has 9mins cooldown.Smite:a vladimir never go for jungleRally:vladimir never plays with attack damage.Cleanse:vladimir has sanguine pool to escape from stuns,silences and other.

Just a brief list of tips and tricks that you should use while playing Vladimir.

1. You can use Sanguine Pool to Permanently drop aggro from turrets EVEN AFTER damaging enemy champions, AS long as their is another target for the turret to fire upon. Ex: A friendly minion, pet, or even another champion.

2. Your Ultimate(Hemoplague) has an excellent reach, See someone recalling too close to their turret but are low health? You can cast your ult on them from outside the turret's range as long as you hit them with just the outside edge of the spell.

3. Level 13+ Don't be afraid to turret dive, Run in and smack the enemy with a Transfusion or your Ultimate and then use Sanguine Pool for an easy escape. By level 13+ your Sanguine Pool cooldown should be low enough so that it will be up the next time you need it.

4. Never initiate with your Sanguine Pool, Save it for extra damage after your ultimate(Level 13+ So the cooldown is shorter) or during iffy battles to help with your retreat.

5. Gank! Vladamir is an excellent ganker. If you are playing center, watch the top and bottom lanes constantly and work with your teammates to set up traps for the enemy champions who push a little too far into your territory. Try to get behind them and use your Sanguine Pool (If it is safe to do so) to slow them down for your friendly champs.

6. Average speed melee chasing you? Do you have Rylai's Crystal Scepter? If so, Cast Transfusion on every cooldown while running. The slow from Rylai's will help you to keep your distance while allowing you to get your health up and maybe even get the advantage on your opponent.

Around level 9+ you should begin to gank. Keep a close eye on the enemy champions in the top and bottom lanes until you see a good opportunity to put yourself behind the enemies and sandwich them with your team without risking yourself. Ex: Their Health is halfway gone or they have no strong disables such as silences, stuns, and taunts. Sneak up behind them via the river in the middle of the map and wait inside the tall grass at either end until the moment comes. Pick a target and signal it to your team via a ping and then make your move, charge out of the grass until you are near melee range with the enemy champions. Cast Transfusion on your target and then pop your Sanguine Pool and path through the enemy Champions to your teammates, this will slow them down and allow you to rejoin up with your team. If your Ultimate is up and there is more than one enemy champion, use it to make sure that no one escapes even if they slip past you and your team.

After each gank, if your health is 40% of higher and you do not need to do any shopping, Just shift back to the middle lane and cast Transfusion till your health is full again allowing you more time gaining experience and money, and spending less time running. Alternate the center farming, single champion killing strategy from above, and ganking bottom or top until you enter the Team Fighting phase.