This is a great build for 5v5, you can start Ryze in MID and control the lane with your Q/W abilities. You will have late game dominance since most tanks like to pick up armor for the AD champs leaving you hungry and becoming fed late game. With the cool down combos you should have no problem scoring Double Kills late game or cleaning up kills your teammates may have missed. Make sure you do not get to close to champs who have high AD, make sure you can get in range to combo your ulti starting with your W ability. How I score a 1.5second kill is R/W/E/Q, NOTE: After this combo your ulti should be around a 20-25 second cool down, so you can tag your enemies with Q/E to cool it down faster then repeat.