Ziggs is always there to help out through the Guardian rune, through his long range abilities and zoning capabilities. This defensive, supportive, artillery play style feels really enjoyable to play if you are more about denying the enemy and enabling your allies.

I prefer Resolve/Sorcery because Ziggs already has plenty of damage and his main damaging ability, Bouncing Bomb has a very short cooldown.

Guardian provides Ziggs with an extra layer of defenses on top of taking Barrier. The move speed and the shield are both fantastic. It can help when running away, helping allies escape (and tanking some damage). I generally just love it because Ziggs only has one escape ability and his only defense is his range.

Demolish is what I take second because it's got some great synergy with his Satchel Charge and Passive. You can often take the enemies first plate very quick.

Bone Plating is what I take third because it's great for trading and taking less poke.

Overgrowth is what I take fourth because I think it's the best option in the row and more health is always welcome.

I've only recently made some real chemistry (see what I did there?) with Ziggs. I had been playing him wrong by not realizing he was an Artillery, I actually had a friend clue me in on this. I used to love the old AP Kog'maw before they nerfed it and Ziggs is kind of my new thing.

Ziggs is fun for me because all four of his abilities are skill shots, he uses explosives and most of all because I suck at fighting (melee, trading, etc). So, Artillery is just kind of my thing where I stand back, help the team and just lob things out there. With the Mad Scientist skin, it almost makes me feel like I'm throwing out potions of healing because I want to keep enemies away from my allies.