I think AP attack speed is the best on teemo, since it keeps his mushrooms viable and still makes his passive auto attack to lots of damage. I would rush malady, but get deathcap before nashor's maybe.
P Ko, try out The Rain Man's build. He's the best Teemo in the game currently, and is over 2300 ELO last time I checked.
He goes AD/AS and you can find his build here:
http://www.solomid.net/guides.php?g=658
He goes AD/AS and you can find his build here:
http://www.solomid.net/guides.php?g=658





Since you won't have the early survivability from the defense tree masteries you will be easier to kill early game. Maybe try starting with a
Doran's Shield to compensate for this. Otherwise I think you will be fine since the other ppl around you's damage will be lower as well since they also have no runes.

AP Twisted Fate | AD Carry Kog | Support Sona
Mowen wrote:
Since you won't have the early survivability from the defense tree masteries you will be easier to kill early game. Maybe try starting with a

If only Riots ****py matchmaking system didn't keep matching me up with 30's who have full runes like it has the last 14 games ;/
Well, hopefully that means that you have some 30's on your team too. If not well... I guess that does happen sometimes, but not usually 14 games in a row. >.> Good luck with that. I'd go with trying to make up defensively rather than offensively though, and buying a doran's shield or getting a health item like
Banshee's Veil or
Guardian Angel earlier than normal. Because like The Rain Man points out you need to be almost in melee range to auto attack with Teemo, so he needs defense.



Thanks to GrandMasterD for my sig!
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At the moment my current build is:
Malady
Nashor's Tooth
Rabadon's Deathcap
Rylai's Crystal Scepter/Frozen Mallet
Infinity Edge/Abyssal Scepter
It's kind of a mess of everything I guess. Any advice?