Okay, does nobody see the problem with this:
Nasus' Siphoning Strike and Fury of the Sands both apply spell vamp. I'm not going to say it's easy to pull off, but I will say it is a game ending monster.

If you don't allow me to tell you:
Runes: AD, Armor, MR/Level, Spell Vamp
Spells: Smite and Flash/ Cleanse
Masteries: 6/11/13
(CDR and minion damage; health/level, minion reduction and damage, armor, health; mana regen, 1 point move speed, summoner cooldowns, mana/level, lifesteal/spellvamp)

End game there should be a Hextech Gunblade among your items....
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