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To further enhance the earlygame, you could also try out AD marks or even Hybrid Pen marks, the attack speed isn't usefull until later and you want to optimize your runes for early game.
One thing I think you can switch out is Runaan's Hurricane for Blade of the Ruined King.It will increase your damage output so much
aradon, Ruunan's is crucial on AP Varus, you really can't substitute it, especially with DFG removed. Without it, your wave clear is awful, and your teamfight presence is weak at best. Runaan's enables Varus to stay relevant, and while BOTRK is decent, there isn't a spot for it in this build. Void Staff/Zhonya's are both better pick ups.
Finally, IMO sorc shoes with some AS runes would be more effective than zerks and mpen runes, but I can't exactly do a calc or anything, so that's open to debate.
I'm also a little dumb and I never fully read the part on his W that gives magic damage on hit...I thought it only did dmg on detonation. Now I must go back into the rift and whip some butt. Also what do you do for your mastery page? I switched mine up at the time of writing this comment, I do 21/6/3.
4 Fury; 1 Butcher; 1 Exposed weakness; 3 Mental force; 1 Arcane Master; 3 Executioner; 3 Archmage; 3 Devestating Strike; 1 Arcane Blade; 1 Havoc;
2 Block; 2 Recovery; 2 Veteran's Scars
3 Fleet of Foot.
I feel the 3 fleet of foot is important for chasing with AA's.