Ashe

Really annoying to lane against as well as more utility.

Take cleanse for all ins after 6

You outscale and she can get bursted easily.

Draven

Very oppressive lane especially when he's paired with an engage support

Just look to farm as you outscale him really hard if he doesn't establish a significant lead

Caitlyn

You will get poked really hard in lane because she is commonly played with mage supports.

You can all in if you manage to bait her e

Sivir

You don't lose the lane in the natural sense. You will 100% never get lane prior against her, go figure giga waveclear > nonexistent waveclear you will have to sacrifice minions for dragon and kills.

Her low range makes it easier to trade with, you can dodge her q with tumble quite easily.

Don't play sentinel or project into her it makes it easier for her to react due to obvious condemn animation.

Nilah

Play off of her w cooldown

Nasus

His wither is very annoying. Cleanse it and kite the hell outta him

Malphite

Attack speed cripple
try not to be the first to show on the map as you will get ulted and locked down.

Ezreal

Vayne favoured but can be a skill matchup depending on how good he is.

All in when his e is on cooldown

Zeri

Same as ezreal its really dependant on the player. However is heavily vayne favoured

Your condemn screws her e up when she jumps over a wall

Aphelios

Aphelios favoured but skill matchup imo

He can poke you out early.

Pay attention to his rotation.
He has point and click cc in his gravitum, but its his weakest gun so an opening would be if he burns his stun giving ~ 10 second window.

maintain distance when he has white to limit his dps

Varus

Miss Fortune

Really annoying in lane, but you outduel her really hard as long as you play around any hard lockdown + her ult cooldown.

When she starts walking up, make sure to back off from you casters so you don't get hit by bounce

Jhin

Jhin himself is usually not the threat. Its the mage supports that give vayne a hard time.

Seraphine

Her abilities are slow and can be easily dodged with your q, just be wary of her ult and bring cleanse.

Don't run at her in a straight line.
q poke her only when her e is on cooldown

Kalista

Kai'Sa