Only play Zoe if you are dedicated to learning a champion, she is very fun but will take a lot of time to fully master. This guide is meant to help out many new Zoe players, and will probably be an easier guide to follow.

For this build, I optimized damage output, and with Rod of Ages adding a bit of sustain. Early game try to clear waves with your Q and try to hit the enemy champion with your Q as well. When you feel confident, start using your E when the champion is not surrounded by creeps. Don't constantly use your E, because it will drain your mana out. Once you have landed an E, throw your Q behind you and recast your Q to where the champion is. Try to auto attack them as well. The Dark Harvest rune will come into use here because when you get them below half, just auto attack them and you will gain a stack of dark harvest. Once you hit level 6 you will be able to finish people of easier. The reason why I build Lich Bane first is because when you R, it will activate the lich bane passive and Zoe's passive, so if someone is low, you can R closer to them, and hit them with an auto attack to finish them. Your R will also be used after you sleep someone to get closer to them to hit them with your Q. You will be able to get fed early, and dominate late game.