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LoL Best Middle Build Guides 2025

Build guides for Middle champions on MOBAFire. Find recommended items and runes by high ranked players to learn the best Middle builds. Create your own champion guide!



2025, Season 2 Guides // Patch 25.10
9.8
1278
Votes
51
LoL Champion Akali Build Guide
LoL Champion Akali Build Guide

[25.10] The Ultimate Guide to Akali the Rogue Assassin

Guide by iwontdominatelol updated May 26, 2025
  • In-depth
9.8
187
Votes
16
LoL Champion Zoe Build Guide
LoL Champion Zoe Build Guide

[25.10] clipbot's Zoe guide for beginners

Guide by Aegox updated May 24, 2025
  • In-depth
9.8
1967
Votes
126
LoL Champion Katarina Build Guide
LoL Champion Katarina Build Guide

[25.10] Nyro Challenger Katarina Build Guide

Guide by Nyrolol updated May 20, 2025
9.8
826
Votes
53
LoL Champion Twisted Fate Build Guide
LoL Champion Twisted Fate Build Guide

[25.10] Twisted Fate guide - Grandmaster, Halfhand 🥇

Guide by Halfhand updated May 18, 2025
  • In-depth
9.8
352
Votes
82
LoL Champion Caitlyn Build Guide
LoL Champion Caitlyn Build Guide

❄️🌙🧁Lethality / Burst Caitlyn Mid (+Crit)(+AD Stack)(All Champion Matchups)❄️🌙🧁

Guide by Zero macro updated May 16, 2025
  • In-depth
9.8
485
Votes
35
LoL Champion Lissandra Build Guide
LoL Champion Lissandra Build Guide

🍦 [ 25.10 - SEASON 15 - The MIDLANE ICE QUEEN OF DEATH! 🍦

Guide by RezoneVerified updated May 16, 2025
  • In-depth
9.8
2306
Votes
159
LoL Champion Yasuo Build Guide
LoL Champion Yasuo Build Guide

[15.9] Tempest's Challenger Yasuo Guide [In-Depth]

Guide by WayOfTheTempesst updated May 15, 2025
  • In-depth
9.8
2571
Votes
127
LoL Champion Yone Build Guide
LoL Champion Yone Build Guide

[15.9] Tempest's Challenger Yone Guide [In-Depth]

Guide by WayOfTheTempesst updated May 15, 2025
  • In-depth
9.7
175
Votes
12
LoL Champion Annie Build Guide
LoL Champion Annie Build Guide

[S15] Rank 1 Annie Complete Guide | By Coach xblademojo

Guide by xblademojo updated May 22, 2025
  • In-depth
9.5
68
Votes
3
LoL Champion Veigar Build Guide
LoL Champion Veigar Build Guide

Guide of an Veigar OTP star zall I Challenger Veigar OTP 1217 LP Peak I

Guide by star zall updated May 26, 2025
  • In-depth
9.5
473
Votes
33
LoL Champion Vex Build Guide
LoL Champion Vex Build Guide

Zianni's Vex Guide

Guide by iZianni updated May 24, 2025
  • In-depth
9.5
364
Votes
29
LoL Champion Syndra Build Guide
LoL Champion Syndra Build Guide

Zianni's Syndra Guide

Guide by iZianni updated May 24, 2025
  • In-depth
9.5
343
Votes
29
LoL Champion Malzahar Build Guide
LoL Champion Malzahar Build Guide

[S15] Rank 1 Malzahar Complete Guide | By Coach xblademojo

Guide by xblademojo updated May 22, 2025
  • In-depth
9.5
975
Votes
76
LoL Champion Kassadin Build Guide
LoL Champion Kassadin Build Guide

[S15] Rank 1 Kassadin Complete Guide | By Coach xblademojo

Guide by xblademojo updated May 22, 2025
  • In-depth
9.5
583
Votes
35
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

💀[NEW SEASON 15] CASSIOPEIA - The POISON Queen of Midlane ☠ 💀

Guide by RezoneVerified updated May 20, 2025
  • In-depth
9.5
863
Votes
48
LoL Champion Seraphine Build Guide
LoL Champion Seraphine Build Guide

❤ 🎶 [SEASON 15 NEW - 25.10] MASTER MID Seraphine! SEASON - THE SONG OF DEATH 🎶🎤

Guide by RezoneVerified updated May 20, 2025
  • In-depth
9.4
106
Votes
14
LoL Champion Talon Build Guide
LoL Champion Talon Build Guide

[25.10] OTP Master Talon Guide with All combos / Season 15

Guide by AmiGo1v9 updated May 19, 2025
9.3
127
Votes
14
LoL Champion Gragas Build Guide
LoL Champion Gragas Build Guide

[25.10] Gragas#Bot's NUCLEAR AP Gragas Mid Guide

Guide by Juon updated May 25, 2025
  • In-depth
  • Off-Meta
9.2
160
Votes
8
LoL Champion Akali Build Guide
LoL Champion Akali Build Guide

Anguishs GrandMasters Akali Mid/Top S15 Guide Patch [15.10] - Every Matchup/Item/Rune explained!

Guide by Anguish333 updated May 23, 2025
  • In-depth
9.2
53
Votes
5
LoL Champion Diana Build Guide
LoL Champion Diana Build Guide

[25.10] [Live] Best Midlane Diana Guide - Diimoonz

Guide by Diimoonz updated May 18, 2025
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AatroxAhriAkaliAkshanAlistarAmbessaAmumuAniviaAnnieApheliosAsheAurelion SolAuroraAzirBardBel'VethBlitzcrankBrandBraumBriarCaitlynCamilleCassiopeiaCho'GathCorkiDariusDianaDr. MundoDravenEkkoEliseEvelynnEzrealFiddlesticksFioraFizzGalioGangplankGarenGnarGragasGravesGwenHecarimHeimerdingerHweiIllaoiIreliaIvernJannaJarvan IVJaxJayceJhinJinxK'SanteKai'SaKalistaKarmaKarthusKassadinKatarinaKayleKaynKennenKha'ZixKindredKledKog'MawLeBlancLee SinLeonaLilliaLissandraLucianLuluLuxMalphiteMalzaharMaokaiMaster YiMelMilioMiss FortuneMordekaiserMorganaNaafiriNamiNasusNautilusNeekoNidaleeNilahNocturneNunu & WillumpOlafOriannaOrnnPantheonPoppyPykeQiyanaQuinnRakanRammusRek'SaiRellRenata GlascRenektonRengarRivenRumbleRyzeSamiraSejuaniSennaSeraphineSettShacoShenShyvanaSingedSionSivirSkarnerSmolderSonaSorakaSwainSylasSyndraTahm KenchTaliyahTalonTaricTeemoThreshTristanaTrundleTryndamereTwisted FateTwitchUdyrUrgotVarusVayneVeigarVel'KozVexViViegoViktorVladimirVolibearWarwickWukongXayahXerathXin ZhaoYasuoYoneYorickYuumiZacZedZeriZiggsZileanZoeZyra
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