Honestly, any of the hook supports are a real pain in the ass. Nautilus, Blitzcrank, and Thresh are other ones. These champions are especially hard to play against if you are lower elo. The main thing to be aware of is that you shouldn't try to get all up in their face and need to keep a bit of a distance. Look out for when he channels his Q, this is the perfect time to use your E.
Seraphine
Seraphine is just really annoying because she has more range than Soraka and a charming ability. If versing her, you'll probably want to play safe and stay out of her range. Focus on supporting your ADC, rather than playing aggressive.
Senna
Senna isn't undefeatable, but she is another annoying champion to play against. You'll want to play safe and probably take Wish over Equinox for your 2nd ability.
Galio
He's just a tanky guy. Leona is another one too, although she's a bit easier because you have more range than her. Soraka is squishy so you will probably need items that give you more health (and/or armor) if versing tanky supports.
Twitch
This invisible rat will beat the crap out of you. He goes invisible, keep that in mind at all times. If the enemy twitch is Level 7 mastery, good luck. It isn't often that you face a good twitch ADC, but when you do you'll probably be under tower during most of the laning phase.
Morgana
Like with the hook supports, Morgana's Q will get you killed if you don't dodge them. She isn't too hard to play against, but you do need to be cautious of her Q and make sure to stay behind minions for safety.
Caitlyn
Cailtlyn is a very good ADC, she's easy to play so you shouldn't need to baby her and can play aggressively. Her traps are great for Soraka's Q and E.
Ashe
Ashe is a champion the enemy team won't want to get close to, which makes her great to play with as a support. She gives you more security so you can focus on playing aggressively, and as long as you keep her alive she will keep you alive.
Draven
Draven is good, he's quite aggressive. However, the pot is very mixed and you can sometimes get really bad and/or toxic Draven players.
Lucian
Lucian is a nice ADC to play with, he's another champion that (usually) makes you feel safe as a support.
Synergies
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Caitlyn
Cailtlyn is a very good ADC, she's easy to play so you shouldn't need to baby her and can play aggressively. Her traps are great for Soraka's Q and E.
Ashe
Ashe is a champion the enemy team won't want to get close to, which makes her great to play with as a support. She gives you more security so you can focus on playing aggressively, and as long as you keep her alive she will keep you alive.
Draven
Draven is good, he's quite aggressive. However, the pot is very mixed and you can sometimes get really bad and/or toxic Draven players.
Lucian
Lucian is a nice ADC to play with, he's another champion that (usually) makes you feel safe as a support.
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