Your runes really don't make much sense. You NEED armor penetration, as all you have now is the six armor penetration from your masteries and the 30 from your SotD active (and that isn't up all the time). There's no Youmuu's Ghostblade, no Stark's Fervor, no Last Whisper, no Black Cleaver. You don't really have the armor penetration to make your damage relevant to a battle. Going instead for attack speed and critical damage makes no sense at all. Sword of the Divine, Phantom Dancer, and Madred's Bloodrazor is already a TON of attack speed. You don't focus much on crits at all, so the Furor quintessences are just wasted.

The choice to use Guinsoo's is a bit strange for me too, as it's a bit more of a hybrid item. Stark's Fervor, Youmuu's, or The Black Cleaver would all serve you far better there.