I'm an ADC main in Gold elo. Yes, my guide may not be as good as others, I just love Vayne. I still have a lot to learn. In this guide I will cover MY version of Vayne! Enjoy :)
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-Vayne as a champion overall is NOT the best ADC to climb with.
-Positioning is a primary ability to play her.
-I feel like she lacks the team-fighting ability that any other ADC's have because
she is better in spots where she can take one at a time, even if they keep coming at her.
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-Vayne is a great top laner, very fun to play.
-Most top champions are melee which allows her to deny them from any CS.
-Vayne's E is great for denying all-ins and setting up ganks.
-Many top laners are tanks. She counters them.
-She's not an actual frontline tank.
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-Jungle Vayne will take patience, her spike isn't till the more mid to late games.
-Ganks are ok, not that great, just jungle.

Either top or bot I believe Vayne should carry the same runes.
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You may change the runes however you want.
Armor Yellows?
~I prefer armor over health over time because it helps you a good amount early game.
b]NOTE[/b Scaling health yellows work better for jungling.
Why one Crit Red?
~That one percent Crit can change your life.
b]NOTE[/b If you are jungling, I recommend switching this to damage or attack speed.
Attack Speed Blue and Reds?
~Vayne is all about attack speed.
WHERES DA LIFESTEAL?
~Not here