Table of Content:
1. Items
2. Masteries
3. Runes
4. Use spells!

At start i get one Dorans Blade with one heal-potion and one yellow trinket. On lane i rush Bilgewater -> Boots -> Blade. Mid Game i go for the red boot thingy and Phantom Dancer. After Phantom Dancer i really like to rush Stattik, u can also buy BT or LW instead. Then u get some defense with Banshees or GA.

I rush 21 / 9 with Vayne, in the Offense i just run the ADC style, got "Feast" to replace the 3rd Lifesteal Quint. Butcher helps y last hitting. Fury kiting with ATK - Speed.

I normally liked to Play with 3 Lifesteal Quints, AD Marks and Glyphs and Armor Seals, since the Lifesteal nerf i replaced the 3rd lifesteal quint with an AD quint. Now i can replace the AD glypsh with MR glyphs, still got 11 AD.

Q-SPELL:
I skill Q first cause u can dominate the Lane with it so well, just use it in the right Moment to Harass and dodge skills. Combine with W .
W-SPELL:
THIS is why LW isnt an must-have, Combine it with the Q.
E-SPELL:
Use it to create distance from enemys, if u shot them into a wall they´ll get stunned for 1.5 seconds.
ULTIMATE ( R-SPELL )
Use it to confuse and kite enemys, Combine with Q to get invisible, increases AD rlly well. Do not use it directly at the start of the fights, use in when ure going to get in Trouble!