Vayne counters Sett because her range lets her poke him safely, and her W deals true damage based on max HP, which is strong against tanky champs like Sett. Her Q helps her dodge his skills, and E can stop his engage. Sett struggles to reach or kill her before getting kited down.
Teemo
Teemo uses range and blind to stop Sett’s basic attacks. His poke and shrooms make Sett’s life miserable in lane.
Kayle
Kayle scales hard, out-ranges Sett, and becomes unkillable late. Her R blocks Sett’s burst, making trades difficult for him.
Quinn
Gwen’s true damage and W’s untargetability help her outduel Sett in extended fights.
Fiora
Fiora parries Sett’s E or W and wins in long trades by proccing vitals. Needs good timing to counter fully.
Jax
Jax scales better and outduels Sett later. His E blocks Sett’s Q and AA damage in all-ins.
Camille
Camille uses mobility and true damage to beat Sett. Needs to dodge his W and play smart around E.
Akshan
Akshan pokes hard and roams fast. Sett can’t reach him unless Akshan mispositions.
Kled
Kled can counter Sett with his aggressive early game and remount mechanic. His Q punishes Sett when trading, and W gives strong short trades. Kled's R lets him engage or roam better. Sett struggles if Kled plays fast and uses his dismount wisely, but if Sett times his W well or survives early pressure, he can outscale.
Gnar
Gnar pokes Sett from range and kites well. Mega Gnar can outtrade Sett with CC and tankiness.
Kennen
Kennen uses range and AoE stun to win trades. Sett struggles unless he all-ins perfectly.
Swain
Swain can out-sustain Sett in fights and pull him out of his E engage. Great in extended teamfights.
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