Caitlyn

Avoid her traps and try to dodge her q early game. Make sure to avoid her abilities by minion blocking, she can turn deadly really quick against Twitch. Your Q cannot escape her ultimate ability once she has locked it in.

Miss Fortune

Her Q will pop you early on, and W slows which ruins your escape/push advantage with Q as Twitch.

Jhin

Anyone with a slow can be bothersome against Twitch, but Jhin's W can root you and give him the chance to 4 shot you. Play safe, try to avoid his abilities and you will be fine late game.

Ashe

Kog'Maw

Slows can cause problems for you.

Corki

Draven

Ezreal

Jinx

Just don't get caught in her traps and you'll be alright.

Kalista

Depends on who is playing her, it's a race to see who can use their abilities stacks first.

Kindred

A pain in the ***

Lucian

Varus

Slows can cause issues, do your best to dodge the Q.

Sivir

Tristana

Vayne

One of the few champs that can pop out of stealth and melt things quicker than Twitch. Make sure to tilt as early as possible if you can.