Hey readers this is Montresor and this is my first guide. I have only been playing Twitch for about two days but i usually carry my games. Please comment after reading and i hope you like it.

Twitchis a very unique character, and I know that all characters are "unique" and "special" but Twitch is part of a small group of champions capable of becoming invisible. This group is Shaco, Teemo, Vayne, Akali, and Evelynn. Only Twitch and Evelynn can use their invisiblity to successfully roam the map unseen. Twitch is typically played as an AD carry despite his abilities using AP. Twitch is very squishy and easily killed in a 1 vs 1 fight. DO YOUR BEST TO AVOID THESE SITUATIONS. I will outline later in the guide when you can engage in a 1 vs 1 fight and win (and hopefully not die). I will also talk more about his abilities and how they should be used as well as what to do when laning.

Pros

You can turn invisible
You deal true damage WITH YOUR PASSIVE! WHAT WITCHCRAFT IS THIS!
Longe range "final blow" to kill others
Even longer ranged ult
Can slow others

Cons

Really squishy
If focused early game can be shut down before you even get started :(
Hard to learn

Twitch is a basic attack based champion with a high natural attack speed, so naturally your rune page should capitalize on these traits. If you truly don't like an all attack speed based rune page then you can put some critical chance runes in there also.

Twitch is built around his basic attack (usually) you want AD masteries and some other masteries to help in other areas.

I take a Doran's Blade to start for an early boost to my AD and then get Berserker's Greaves for extra attack speed. Because Twitch is very squishy and has no abilities to sustain him i buy a Vampiric Scepter for life steal and start to build a IE. Start with Cloak of Agility and then buy B. F. Sword and then your Infinity Edge. Once you have an IE you start dealing lots of damage and should then work on getting a Zeal so you can build a Phantom Dancer. Next you are going to want some more sustain so you buy another B. F. Sword and then build a Bloodthirster. Because of your naturaly high attack speed as Twitch items with an on hit effect are very effective so i get a Black Cleaver in case someone on the other team is trying to counter me (and you know they are) with some armor. Finally I sell my Doran's Blade and buy a Wit's End

Get Ambush first so you can check the bushes in your lane and so that you have a tool for escaping, ganking, and a quick attack speed bonus. Next get expunge because this is how you get the kills. Put another point in Ambush next to increase bonus attack speed and the time spent invisible. I can guarantee that you will love that extra amount of time which is why I prioritize it over Venom Cask. You need at least one stack of Venom Cask before lvl six. You want to max expunge first, then Ambush, and then Spray and Pray, ending with Venom Cask. I will explain why later.

good spells
you are breaking my heart is you don't take flash with you ;_;

you should take this for sustain and to piss off whoever you might be laning against XD

I dare to mess up using this, I DARE YOU

ok spells
its a good spell, but its kinda a waste in my opinion since you have your W .....

if you pick any other summoner spell (except maybe smite) besides the ones listed above then you hate me, hate twitch, hate all the other players who like twitch and want to die!

Usually you want to lane top (although i have heard of people successfully laning mid or jungling) and only lane bot if you have a great support with you. Because Twitch is very squishy you need to play "passive-aggressively". This is where you mainly farm and wait for your opponent(s) to make the first move. Because LoL is a generally fast-paced game very few players have the patience to not engage the enemy early on. The good thing is that you only have to have more patience than your opponent(s). Once they come closer to try and engage you, you get very aggressive and start beating the **** out of them with your basic attacks and ambushing them if you must. Most people are unaware of the range of expunge and of just how much damage it does with six stacks of Deadly Venom. So once they retreat to lick their wounds you can pursue to whittle them down to enough health to kill them with expunge. Eventually you are going to roam, its just unavoidable. Usually you want to wait until you have pushed down the first tower in your lane before you start roaming. When laning you need to be careful of characters that excel at harassing you, such as Lux or Nidalee.

Some people reading might be wondering: "Why do you max expunge first? Why not max ambush? And why do you max your slow last?" Your slow so is great for escaping or for chasing, yes. But unless you are fed you are using your slow mainly to escape because you are going to make me cry if you are chasing someone before you are fed ;_;. Expunge needs to be maxed first because it is your only damage dealing ability and has a great range. With expunge you can make an enemy think that retreating at the moment before they drop to too low of health will work. Then you active those six stacks of deadly venom you placed on them and wait for the cursing to come from the chat box. You need ambush next because this is what makes you so troublesome. No one ever knows whee you are later in the game if you get good as Twitch. Many players also don't realize how amazing you ult is. I will now tell you a true story of a moment in one of my matches with Twitch: I was roaming around he map invisible when i noticed a fed Cho'Gath making his way towards baron and started heading to baron also. I found him attempting to solo baron and waited for him to get low on health. Then Ashe bursts out of the woods to help him and i knew that a double kill was calling my name. I positioned myself so that they were in a line and activated my ult so i could shoot them both killing Ashe outright and then activating expunge for the double. This is a completly true story.

Its only ok to 1 vs 1 when: you start the fight by coming out of invisibility to utilize the attack speed bonus from ambush; when the other character is at least as squishy as you; and when you know that is 1 vs 1 and they have no allies nearby to help.