Pros
.Great Carry
.Stealth
.Good pusher
.One of the best last hitters
.Great ganker
.Good slow

Cons
.Squishy
.Can be countered with oracles and wards

Always try to get mid, it's the best lane for Twitch as he get strong quicker to gank more.

REMEMBER:Your enemies HATE your poison, so use it to make the enemy away to farm better, do it until he gets 50% Health or lower. Then move to a bush and activate Ambush , stay behind your enemy and attack! Now, 2 things can happen:

A: The enemy gonna fight until someone die (activate Expunge Expunge when you get 6 stacks of your passive), I mean, until HE dies.

B: The enemy can try to run away, just activate your and Expunge Expunge

Conclusion: Both alternatives will have the same end: YOU HAVE SLAIN AN ENEMY


Standard Combo

- - - Expunge

- The perfect boot for twitch, it gives you some decent attack speed early games that is essential for early game kills. Why not Boots of Mobility? I don't like these boots because they don't give the power to reach 1900 attack speed late game and you will have decent move speed late game with this build.

X2 - Pretty good item that gives you a lot of attack speed, movement speed (that's with Boots of Mobility are useless) and critical strike. The attack speed works perfectly with life steal, more attack speed - faster you attack, faster you attack - faster you life steal.

- A good item that gives you a LOT of life steal and attack damage, don't forget to get it for max survivability.

- Don't forget to get your Infinity Edge, it gives you more critical, what makes your attacks hit about 500 90% of the times, with 1900 attack speed! AWESOME!!

- Good item to get late game, because it gives you pretty decent health that is useful to survive the team-fights late game.

While playing Twitch, a big problem is players with oracles and wards, they will use it to see you while in the stealth form and this can cause you to die many, many times. But with the right technique, you can easily counter they.

Wards:
ALWAYS check if your enemy has some wards in the inventory, if the have, a good way to counter wards is buying oracle's elixir, because wards are stealth, with oracle's you can find wards, and destroy them.

Oracle's Elixir
If your enemy has that pink eye in the head, he has oracle's elixir! A good way to counter it is saying to your team to focus on killing that player with the elixir, when he dies... problem solved!

In my opinion Heal and Flash are the best spells for Twitch, Heal will be quite useful as Twitch is squishy, you can use it many times to lure enemies and get pretty easy kills. I like to take Flash because when Twitch activate his stealth, he can't start it until he get no damage for a short time, with flash, in team fights when an enemy chase you, you activate flash and stealth and... you survived!

You can also pick:

and

Exhaust and Ignite are good spells too, you can use them to be more offensive, but don't pick both, choose one to use with Flash.

1.You always should use you passive to the MAX, dont forget to put many stacks before activating your "e" ability

2.Your first ability is called Ambush for a reason... Ambushes!

3.Your ultimate can hit multiple targets, use it to put stacks of your passive on the entire enemy team!

4.The easiest way to escape with Twitch is: "W", Flash , stealth.

5.Use your stealth to trick enemies, enter in the bush and stealth, the enemy will think u are in the bush and you can do a good surprise attack!

6.The last thing you can't forget is that my English isn't so good because i'm not american, I live in Brazil =D

So, that's it, make good use of Twitch, The Plague Rat, I love him, actually my FAVORITE champion!