Are you tired of the Classic Vayne - ADC build? This build Im about to share is for Fun only ( because supposedly Vayne plays bot lane ). I usually build this when I play Top or Mid lane. so Try to dish out some Insane DMG in just one Tumble ^^

With the introduction of Duskblade of Draktharr, this opens up the new possibility of some crazy AD burst. Since Vayne's Ultimate give her additional damage and the ability to go Invisible ( Tumble ) , She has the potential to Burst down foes easily.

Why Rapid fire cannon instead of PD or sick shiv?

for spells, Flash is a must. You can choose between Heal and Cleanse. Heal gives you the burst movementspeed and Cleanse helps you to deal against CCs. on masteries, I pick Warlord's bloodlust as the Keystone because you will not build Lifesteal Item. your crit chance is fairly enough because movementspeed and attackspeed bonuses help to energize frequently. Use the keystone Thunderlord if you want the real Assassin's burst dmg.Because the point of this build is to burst down enemy in just one Tumble. Rapid fire cannon's energize is stronger than statik shiv. so with Trinity Force spellblade + Rapid Fire Cannon energize + Duskblade nighstalker, a big burst of Damage to a single target, completely assassinated.

Try to utilize your tumble well so that every AA will proc the passives.