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Threats & Synergies
Elise is a tricky one, she has hard CC and decent damage. When at low health, Play very defensively as her Spider form's Bite deals more damage the lower your health is. if she uses Rappel to engage, then she has no escape. There are not too many decent Elise players out there though.
Can be difficult to deal with, even when he is at low health. Be careful if he is running away from you as he can always turn with a bodyslam and burst you down very quickly if you are chasing him. Good sustain and plenty of damage, avoid fighting with him early.
Nunu & Willump
This is just a pain in the ass. After a few levels you should have no problems 1v1 with him, but don't underestimate him either as he can still pack a punch and stick to you with his (E)
Luckily there are few decent Shaco players out there. In the right hands though, he will cause you plenty of trouble until you get some items. He has as much cheese going for him as Twitch does, and that's saying something as Twitch is a Rat.
He is tanky and can chase you down. Not the worst to Jungle against but try to not let him set you behind, else it will be difficult to catch up again.
CC and Tanky, you should have no real issue with him in the early game apart from counterganks. He can be a right pain to deal with though as the game progresses. Remember he has a lot of range when he leaps into a lane, this can catch you out very easily if you are in the middle of ganking a lane.