I believe that K'sante doesn't have very difficult matchups in the mid lane. The most challenging ones are those where you can't kill your opponent, but in such cases, you can start roaming, and you scale well on your own."
Talon
Talon is not a difficult matchup; the key is to time his W + Q combo with your W to nullify his damage. You're almost always stronger than him. The only issue is he can jump over walls, so keep track of which walls he's used and ult in the opposite direction to prevent his escape.
Twisted Fate
Easy matchup because Twisted Fate will never be able to escape from you. Take Fleet Footwork for sustain in lane. The crucial part is to activate W when he throws the yellow card at us. Look for good ultimates to kill him; when he's out of cards, he's useless.
I prefer taking Ghost/Ignite because now tf always go flash/ghost. Always be ready to use crowd control after ulting through a wall, as the enemy Twisted Fate can simply teleport away from you during his ult (in some situations, you can ult through a wall and, if he teleports, cancel your ultimate and interrupt his teleport cast with our W). Currently, he is opting for a hybrid build due to buffs, so I prefer taking Zeke's, a very cost-effective item that prevents Twisted Fate from escaping. MR items are also good, but he can still escape without being slowed using Ghost and Flash
Karthus
Easy matchup, take Fleet Footwork for sustain in lane. Kartus can't escape from us; one good combo with the ult always kills him. Dodge his Q ability, and if he ults, don't forget to press E + W (or whatever is available if either is on cooldown). This way, he'll hardly deal any damage.
Lux
Easy matchup, take Fleet Footwork for sustain in lane. The key on this lane is to press W every time she combos and to use W for her Q if it's a guaranteed hit. Lux often exposes herself to combos with our ult, leading to an easy kill
Yuumi
Just kill her, lol.
Katarina
Easy matchup, you can choose the rune as you like. Katarina can't kill you 1v1 (unless she's 10/0 but even then its hard to die), just hit her if she gets aggressive. Use W during her ult, try to combo her, and toss her over a wall with the ultimate to kill her .
Akali
Aurelion Sol
Ahri
Hwei
Diana
Pantheon
Annie
LeBlanc
my permaban
Azir
Yasuo
Ekko
Ekko is a very easy matchup; I recommend taking Grasp because we can often proc it against Ekko. With our W, we block all of his damage and also the stun from his W. You can bait Ekko's ingage when he press w u just use your W to block all the damage and stun. The only issue with Ekko is that if we ult through a wall, he can simply return with his own ult. Therefore, we shouldn't ult into a wall if he has his ult. With Grasp and well-timed W, we always win trades. I suggest going for Kaenic Rookern => armor item => Jak Sho or starting with Tear => Kaenic Rookern => Winter's Approach => Jak Sho.
Or buy jak sho second item
Cassiopeia
Malzahar
Malzahar isnt difficult matchup, but there's nothing particularly difficult about it; the only challenging part is timing your W to interrupt his ultimate. I recommend getting Hollow Radiance as your first item against him. This way, we won't have any issues with pushing and can easily break his passive with the Hollow Radiance proc. Additionally, his Voidlings are affected by Hollow Radiance, providing us with even more lane push and a better chance to break his passive. If you time your W to interrupt his ultimate, you can kill him.
Personally, I take Flash/Teleport or Flash/Ignite. Ghost won't help us much in catching him, as he always has his ultimate.
Yuumi
Do I need to explain?
Orianna
Shen
just a good R
Briar
During Briar ganks, we can see where she is casting her ultimate and in which direction, allowing us To position the opponent directly under Briar's ultimate with our W and R to guarantee a 100% hit on her ultimate. In practice, it can be quite challenging, but if your friend is playing Briar and he is in Discord with you, or if the Briar player is good and he pinging where exactly she is casting her ultimate, you can easily execute this strategy.
Kalista
Bard
If Bard hits a good ultimate, we can line up all the enemies he hit with our W and ult in the direction we want.
Ashe
Anivia
Synergies
IdealStrongOkLowNone
Yuumi
Do I need to explain?
Orianna
Shen
just a good R
Briar
During Briar ganks, we can see where she is casting her ultimate and in which direction, allowing us To position the opponent directly under Briar's ultimate with our W and R to guarantee a 100% hit on her ultimate. In practice, it can be quite challenging, but if your friend is playing Briar and he is in Discord with you, or if the Briar player is good and he pinging where exactly she is casting her ultimate, you can easily execute this strategy.
Kalista
Bard
If Bard hits a good ultimate, we can line up all the enemies he hit with our W and ult in the direction we want.
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