Click to open network menu
Join or Log In
Mobafire logo

Join the leading League of Legends community. Create and share Champion Guides and Builds.

Create an MFN Account






Or

Caitlyn Build Guide by NeverMisses

ADC [25.22] Air Strike Caitlyn

ADC [25.22] Air Strike Caitlyn

Updated on November 9, 2025
New Guide
Vote Vote
League of Legends Build Guide Author NeverMisses Build Guide By NeverMisses 6,204 Views 0 Comments
6,204 Views 0 Comments League of Legends Build Guide Author NeverMisses Caitlyn Build Guide By NeverMisses Updated on November 9, 2025
x
Did this guide help you? If so please give them a vote or leave a comment. You can even win prizes by doing so!
Vote
Comment

You must be logged in to comment. Please login or register.

I liked this Guide
I didn't like this Guide
Commenting is required to vote!
Would you like to add a comment to your vote?

Your votes and comments encourage our guide authors to continue
creating helpful guides for the League of Legends community.

Runes:

Inspiration
First Strike
Cash Back
Triple Tonic
Jack of all Trades

Sorcery
Absolute Focus
Gathering Storm
Bonus:

+10% Attack Speed
+9 Adaptive (5.4 AD or 9 AP)
+10-180 Bonus Health

Spells:

Spells
LoL Summoner Spell: Barrier

Barrier

LoL Summoner Spell: Flash

Flash

Threats & Synergies

Threats Synergies
Extreme Major Even Minor Tiny
Show All
None Low Ok Strong Ideal
Extreme Threats
Ideal Synergies
Synergies
Ideal Strong Ok Low None

Champion Build Guide

[25.22] Air Strike Caitlyn

By NeverMisses
Itemization Notes
Why This Build Works:

Why This Build Works:
Infinity Edge first: Maximizes crit damage on Caitlyn's headshots - headshot crits deal massive damage
The Collector: Executes low-health targets and provides lethality + crit, synergizes with R
Lord Dominik's Regards: Giant armor penetration for tank shredding
Rapid Firecannon: Extends Caitlyn's 650 range to 800+, makes her the safest ADC in the game
Bloodthirster: Massive lifesteal and shield for sustain


Build Path Philosophy:
IE first on Caitlyn works because her headshots scale with crit damage. With First Strike generating bonus gold, you accelerate into expensive items faster. The combination of crit, lethality, and armor pen provides damage against all target types. RFC is essential on Caitlyn - it makes her range advantage even more oppressive.
Gameplay Tips
    Range Advantage: Use Caitlyn's 650 range to proc First Strike safely
    Headshot Poke: Headshot autos trigger First Strike for bonus gold
    Trap Control: W traps provide zone control and guarantee headshots
    Net Positioning: Save E for escapes since you have no defensive items early
    Ultimate: R executes pair perfectly with Collector threshold
Early Game (0-15 min)
    Focus on CS and proc First Strike whenever possible for extra gold
    Use headshot harass to dominate lane and stack First Strike gold
    Rush Infinity Edge components (B.F. Sword priority)
    Use Triple Tonic potions for sustain advantage
    Place W traps in bushes to control vision and get headshot procs
    Aim for 6-7 CS/min
    Barrier allows you to trade aggressively and survive all-ins
Mid Game (15-25 min)
    Complete Berserker's + Collector for execute damage
    Look for picks with Collector execute threshold
    Rapid Firecannon extends your already-long range to 800+ for siege
    Stay above 70% HP to maintain Absolute Focus bonus
    Use R (Ace in the Hole) to finish low targets from extreme range
    Set up trap zones around objectives before fights
    Your range + RFC lets you siege towers safely
Late Game (25+ min)
    Gathering Storm gives massive AD scaling
    RFC + 650 base range = safest ADC positioning in game
    Use Firecannon + headshot combo to chunk tanks before fights
    Bloodthirster sustain lets you duel more confidently
    LDR shreds tanks, Collector executes squishies
    Place trap lines to zone enemy frontline from your position
    R can secure kills from 2000+ range with IE + Collector execute
    Use Barrier defensively - it's your only survival tool
Download the Porofessor App for Windows
League of Legends Build Guide Author NeverMisses
NeverMisses Caitlyn Guide
Vote Vote
[25.22] Air Strike Caitlyn

League of Legends Champions:

Teamfight Tactics Guide