This Vayne is made for people who like to farm and not to engage, with this you can takedown almost any champ with 3 or 5 hits

Flash is the most important spell it can be both aggressive or defensive and since you have tumble and condemn nobody can catch you and you passive assure nobody will flee from you
Remember only use flash when there is no escape it can save your life in many occasions

Barrier compensate her weak body, Vayne is pretty squishy so everytime you get half life on a fight activate your barrier and continue fighting

Cleanse i don't recommend since barrier can protect you while you are stunned and you will probably won't take many CC if you don't enter in the team fight

Ignite it's a good spell but you won't have range to cast it out of the teamfight

Exhaust let your supp get this you won't use it many times

Now let's talk about your combos

Harrasssssss
When you got your ruined king blade you can finally get a good damage and if you end up gaining the blue buff torture the soul of the enemie ADC with this
Tumble+ basic attack+ Condemn+ basic attack
you probably do 200+ damage with tumble and basic attack, condemn dont do any considerable amount of damage but the enemie will get too far to reply your harras, the second basic attack will do 4-8% of enemie health and 100+ damage and will be done right after de condemn so you can flee after the 3 hit were applied without taking a hit

Flash and wall
Your enemie is half health and the jungler is at top time to destroy all the hope of surviving that he could have
Flash+ Tumble+ Condemn+ Attack till the death
You can walk enormous distances with flash and tumble use it to send your enemie to the wall and is a kill granted

Flee from the beat
Your tumble has 2 sec CD at lvl 5 but it only enter on CD after a hit and you ar trying to flee from that gum on your shoe time to learn how to leave him eating dust
Tumble+ Basic attack+ Ruined King+ Tumble+ Basic attack+ Condemn+ Tumble+ Basic attack
This combo gives you 12 sec of advantage of your enemies.
PS:stun destroy this combo

Champ Combos
Vayne+Blitzcrank

GET over/out of HERE
Your enemie is fooling around teach him a lesson shaking him to the ground
Rocket punch+ Tumble+ Condemn
Stay near blitz and when you see he is gonna get someone tumble on enemie back and make he meet your obelisk

Mid air dragon killing of the shades of night
It's possible with some sync to make the enemie crash on blitz hand and stunning him at the same time.
First: Find an enemie fooling
Second:Rocket Grab
Third:Before the enemie starts being pulled toward blitz use condemn
Forth:Watch enemie crashing on blitz iron chest
Fifth:Do the part of dragon, shade and night

Alistar+Vayne

Lift and send to the moon
Pulverize+ Headbutt+ Condenm
Doesn't need any explanation

Taric+Vayne

Gems are outrageous(with) silver of the moon
Ezreal is dancing in the middle of your lane flash tumble condemn in the direction of the bushes Taric will hug him with crystal shards

It's your way to live, your air, and your blood.
Kill all the minions you can
PS:They must be already dying and under the tower