Perma Ban Tahm Kench if Possible. He zones you effectively has unpredictable engages through vision and Scales just as hard with his Heartsteel and his CC and synergy with Kill High Mobility High Damage early Champs like Lucian Draven and Nilah.
Pyke
Pyke is a very 50/50 although he should be able to run you down early game. His engage is easy to dodge and very telegraphed while also being capable of being poked out or being made useless in a freeze or tower hugging gameplay which is often required for Senna ADC.
Swain
Swain early isnt too bad having short range engages and poke but the issue with him is that he will scale he has very big timers where he is super powerful on his first item spike second item spike and whenever he gets ult or is on Objectives. He will scale just as well also becoming a raid boss around mid game but is doable whenever it is even later in the game or if your team has anti heal or can 100-0 him before he gets the chance.
Kayn
Kayn is a gank heavy jungler that favors ganking bot if he is looking for blue kayn. If you see his runes and it is harvest or first strike and his team is already tanky he is most likely going blue Kayn which means he will spam gank you at any opportunity. Good lane mangement and wards here and there should do the trick but its best to play safe and freeze or tower farm until its time for teamfighting.
Pantheon
Is really strong early game and has a deceptively high engage range and is impossible to dodge because it is point and click. Is doable since he falls off super hard but his early game damage and threat to assassinate you just for existing is too much to risk. Lane management and support synergies can help with this. You WILL eventually be able to just kite him and kill him and most likely the supports will go full lethality instead of bruiser so he will be able to be ran down with your range and damage come mid game.
Rammus
Rammus is the bane of existence for any ADC or attack damage focused champion his ganks are great he has a **** ton of health and armor you will outscale and eventually be able to kill him but he is going to be a nuisance without good vision or help from jungle and support.
Zed
Zed is probably the worst matchup you can face. He has range he has execute can dash can dive just be wary if you ever see him missing as he can at any point just ult in ignite and leave unscathed.
Alistar
He does virtually no damage but has a really fast and unpredictable engage super tanky and can dive you at any time with some coordination but 1v1 you win all the time not worthy of a ban but with a good team he can wreck you.
Fizz
For all the same reasons as Zed yeah...
Aphelios
Scales super well a strong 1v1 duelist and his laning and wave clear is superior a gank to put him down early while you freeze the wave will be enough to even the playing field.
Kai'Sa
Relatively covers the same identity as Senna. Senna has an upper hand in terms of range and overall team value but when she scales and gets a few items she is formidable and has global pressure just as you do and even better mobility. With good spacing and teamwork you can use that range advantage to win fights with her.
Zeri
Easiest Lane for Senna she is very reliant on her support but in lane it isn't much of an issue. With a strong support by your side you can easily win lane and offer much more to the team than her. Late game she does scale but nowhere to the magnitude that Senna does. 1v1's she may have an advantage but overall team value she falls short.
Vayne
Same as Zeri heavily reliant on support but has lacking range compared to you. Offers very little to the team while 1v1ing her might be close throughout the game she can't match your tempo and things you offer for your team.
Milio
Best enchanter to keep you alive. Godly heals consistent peel and gives you a free blackfire torch for your autos just by existing.
Karma
Strong Early can keep you alive with decent peel and good versatile support to shield and give you movespeed offensively and defensively. Strong area of denial with her Ult Q to keep the divers at bay while you farm. Has enough damage to poke the opposition out of lane herself.
Ashe
Whether she is the ADC or the SUP with both of your range combines should equate to a decent lane the ashe should be playing aggressive constantly poking and trading autos with the opposing team with the combination of Senna.
Amumu
Whether it is Amumu JUNG or SUP Senna will be heavily reliant on a tank in front of her to lock down enemy champs while she dishes out damage while also being able to peel and support them when needed although when it comes to tanks they usually bite off more than they can chew and you need to not be baited by your own teammates and risk your precious lead.
Shen
Another tank but better than Amumu. Decent CC great damage for a tank and can protect you just as well as you protect him. Rely on his Ult as much as he relies on yours forming a good bond with the Shen is crucial as you two are capable of affecting the team globally.
Galio
For all the same reasons as Shen rely on him heavily if he isn't already your support. Roam with him looking for fights ult him whenever you need to and he will return the favor.
Jhin
Best Synergy with Senna Support Senna can help keep him safe and dish out damage while he is dealing with his horrendous early farming. Constantly look for auto trades and Q and W's he can play off of and stick near him as much as possible as you two control the whole map together and can join fights in the blink of an eye with your range and movement speed.
Caitlyn
Better in Lane together but worse after. Caitlyn isn't particularly strong early nor does she scale super well. But the two of you together in Lane and in teamfights have excellent range and target access. With your ults.
Taric
Strong early good defensive and peeling capabilities. But is relatively unpopular and hard to master so this link up is relatively unlikely but isn't a bad pairing at all.
Cho'Gath
Great for fasting Senna or just in general having a big guy like him is very beneficial whether you're the ADC or Him has strong CC and kill pressure scales just as hard as you do and is a menace on objectives.
Tahm Kench
For all the same reasons as cho strong early keeps you safe soaks up tons of damage. And scales hard.
Sona
Although you would think two hyper scaling champs in bot lane would be useful she doesn't offer much in terms of defense in lane her late game support is massive but its all for nought if she can't protect Senna. She has very little pressure and very little peel early on which is crucial for Senna as she needs that early game insurance from dives and hard engages.
Yuumi
Same as Sona good scaling but lacks early game protection and very little pressence.
Synergies
IdealStrongOkLowNone
Milio
Best enchanter to keep you alive. Godly heals consistent peel and gives you a free blackfire torch for your autos just by existing.
Karma
Strong Early can keep you alive with decent peel and good versatile support to shield and give you movespeed offensively and defensively. Strong area of denial with her Ult Q to keep the divers at bay while you farm. Has enough damage to poke the opposition out of lane herself.
Ashe
Whether she is the ADC or the SUP with both of your range combines should equate to a decent lane the ashe should be playing aggressive constantly poking and trading autos with the opposing team with the combination of Senna.
Amumu
Whether it is Amumu JUNG or SUP Senna will be heavily reliant on a tank in front of her to lock down enemy champs while she dishes out damage while also being able to peel and support them when needed although when it comes to tanks they usually bite off more than they can chew and you need to not be baited by your own teammates and risk your precious lead.
Shen
Another tank but better than Amumu. Decent CC great damage for a tank and can protect you just as well as you protect him. Rely on his Ult as much as he relies on yours forming a good bond with the Shen is crucial as you two are capable of affecting the team globally.
Galio
For all the same reasons as Shen rely on him heavily if he isn't already your support. Roam with him looking for fights ult him whenever you need to and he will return the favor.
Jhin
Best Synergy with Senna Support Senna can help keep him safe and dish out damage while he is dealing with his horrendous early farming. Constantly look for auto trades and Q and W's he can play off of and stick near him as much as possible as you two control the whole map together and can join fights in the blink of an eye with your range and movement speed.
Caitlyn
Better in Lane together but worse after. Caitlyn isn't particularly strong early nor does she scale super well. But the two of you together in Lane and in teamfights have excellent range and target access. With your ults.
Taric
Strong early good defensive and peeling capabilities. But is relatively unpopular and hard to master so this link up is relatively unlikely but isn't a bad pairing at all.
Cho'Gath
Great for fasting Senna or just in general having a big guy like him is very beneficial whether you're the ADC or Him has strong CC and kill pressure scales just as hard as you do and is a menace on objectives.
Tahm Kench
For all the same reasons as cho strong early keeps you safe soaks up tons of damage. And scales hard.
Sona
Although you would think two hyper scaling champs in bot lane would be useful she doesn't offer much in terms of defense in lane her late game support is massive but its all for nought if she can't protect Senna. She has very little pressure and very little peel early on which is crucial for Senna as she needs that early game insurance from dives and hard engages.
Yuumi
Same as Sona good scaling but lacks early game protection and very little pressence.
My ADC Senna
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