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Nunu the Hybrid Jungle-Devourer
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Nunu can clear out large monsters in the jungle quickly which will add stacks to Ranger's Trailblazer - Devourer.
Wit's End will increase Nunu's clear speed through the jungle and help to strip opposing champion's of some Magic Resistance.
Mercury's Tread ensures that opposing Champions have extreme difficulty grabbing ahold of the dynamic duo ( "Can't catch me!" ).
If you're facing champion's with high levels of lifesteal/spellvamp/sustainability ( ) you can add Morellonomicon after Wit's End and Black Cleaver to really strip them of the sustain they depend on.
Example of final build for Anti-tank needs:
If your team needs someone to absorb damage and act more as a true tank, adding Frozen Heart and Banshee's Veil will allow you to do just that (Frozen Armor will also give you an additional 20% CDR, which gives you a full 40% CDR).
If the opposing team lacks a lot of hard CC, adding Abyssal Scepter will give you both Magic Resit and you'll deliver a more powerful attack from Nunu's ultimate, Absolute Zero.