I have played Vladimir a lot, building it differently every time. Finally after endless experimentation and fail this build has solidified.

Summoner Spells

Ghost-Works very well on Vlad, if you pop it before Sanguine Pool you will slide away from anything like a baws.
Ignite-Take this if you want more burst, or against healers/regen*****s
Flash-Take instead of ignite. Early game gets a bit weaker, but having no means of dashing, this is a great spell

Runes

Scaling Armor and Magic resist - You don't want to itemize defensive stats, because gold is better spent on AP, HP and MPEN. Late game your HP would make any Mundo jealous, and adding some armor and magic resist your effective health will be massive.
Magic Penetration - Stacking magic penetration is a good thing to do. Your spells will hit like a truck. Interestingly the more you stack, the stronger each point gets ( the inverse of defensive stat stacking - armor and magic resist get less efficient the more you stack it). Synergism with Abyssal Mask, Sorcerer's Shoes, and Liandry's Torment.

Masteries

Maximize damage amplification - 21 points on offense
Some survivability - 9 points in defense

Start

Doran's Blade - It was a strange idea I had, but it works fabulously. It GREATLY helps you last hit (especially if ur nab like me), restores 5HP per Autoattack and gives 80 health.
Amplifying Tome - Take this if you don't believe me, but then why are you reading this?

Early game

The Doran's Blade combined with Transfusion will keep you healthy as long as you don't push like a newb. Don't use Tides of Blood for pushing when you get it at level 4. If you manage, farm up to a Hextech Revolver and Boots. Farm more, and get Sightstone first, and Sorcerer's Shoes afterwards as soon as possible. The Sightsone allows you to push like crazy, and gives you and your team intelligence on the enemy. Once the lane is pushed, don't stay around like a ******* derp, go and pick up some kills and assists.

Late game

You will get very strong - extremely strong - but don't go in solo Rambostyle like myself... stick with the team, Because Hemoplague is a great resource.

Sun Tzu clearly speaks about Vladimir in Art of War. Here is some wisdom:

“Hence a commander who advances without any thought of winning personal fame and withdraws in spite of certain punishment, whose only concern is to protect his people and promote the interests of his ruler, is the nation's treasure. Because he fusses over his men as if they were infants, they will accompany him into the deepest valleys; because he fusses over his men as if they were his own beloved sons, they will die by his side. If he is generous with them and yet they do not do as he tells them, if he loves them and yet they do not obey his commands, if he is so undisciplined with them that he cannot bring them into proper order, the will be like spoiled children who can be put to no good use at all.”

“Do not repeat the tactics which have gained you one victory, but let your methods be regulated by the infinite variety of circumstances.”

“Those skilled at making the enemy move do so by creating a situation to which he must conform; they entice him with something he is certain to take, and with lures of ostensible profit they await him in strength.”

“A clever general, therefore, avoids an army when its spirit is keen, but attacks it when it is sluggish and inclined to return. This is the art of studying moods.”

“To know your Enemy, you must become your Enemy.”

“When the enemy is relaxed, make them toil. When full, starve them. When settled, make them move.”

“All warfare is based on deception.”

“If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat. If you know neither the enemy nor yourself,
you will succumb in every battle”

“Engage people with what they expect; it is what they are able to discern and confirms their projections. It settles them into predictable patterns of response, occupying their minds while you wait for the extraordinary moment — that which they cannot anticipate.”

So much wisdom
Have fun bye