Q into E

Your main combo for landing a stun. You want to if possible land a Dark Sphere onto an enemy and use Scatter the weak on the sphere to launch it through your enemy to stun them. You can however place a dark sphere on the ground and launch it into your enemy to stun them. This combo also works as a really strong disengage tool if you get ganked.

Basic Ultimate combo Q, W pick up, W drop, E, R

You use this to quickly bring down an already lowered hp target quickly. Your ultimate scales also with the amount of spheres on the ground and this allows you to do probably 75% hp of ur enemys hp when u use it.

5 Sphere Ultimate Combo Q, W pick up, wait for Q off cool down, Q, W drop, E, R

This combo is similar to your basic ultimate combo except this will more than likely 100 to 0 your enemy if they are squishy. Requires more preparation than the previous combo but is likely to secure a kill.

6 Sphere Combo Q, Q, W pick up first sphere, W drop, Q, E, R

This combo requires the most preparation but can probably do around 2000 damage when u have ur main items. This is for tankier targets.

There is guides out there that mention a 7 sphere combo but in practice the time to set this up isnt worth it as you will likely have been focused by the time u can set it up. This also requires the CDR cap to be hit to be able to set up also basically same as 6 sphere but an extra q at the beginning.