Hey, I'm a Diamond level player that mains the role of ADC (Attack Damage Carry). Vayne is an exceptionally strong hyper-carry ADC which means that her late game outscales almost all other AD Carries. With Vayne, strong positioning and kiting is necessary in order to scale to late game where Vayne can truly dominate!

Summoner Spells

Runes

This item is considered one of the bread and butter items when playing Vayne Blade of the Ruined King provides everything Vayne needs in her kit: Lifesteal, Attack Damage, Attack Speed. This item also provides a very helpful active which takes away a percent of the enemy's life it is used on while stealing 25% of the target's movement speed for 3 seconds which allows for repositioning.

Berserker's Greaves, the standard item for AD carries, provides attack speed and mobility.

Phantom Dancer provides attack speed, critical strike chance, and mobility. Also allows for movement through units and works well with Infinity Edge.

Provides 40 flat AD. The unique passive is what makes this item so vital and strong on Vayne. Ignoring 35% of the targets armor (applying before armor pen), is vital to melt through tanks.

Infinity Edge is also one of the standard items to have as an ADC. This item provides 80 flat AD, as well as 25% critical strike chance. The unique passive is also great as critical strikes now deal 250% damage instead of 200% which increases damage input with crit. As mentioned earlier, this item works well with Phantom Dancer as well as Statikk Shiv

Youmuu's Ghostblade is a great item to have on attack speed based ADC's such as Vayne, Twitch, and Lucian, just to name a few. This item provides 30 flat AD, 15% critical strike chance, and 10% cooldown reduction. The unique passive also grants 20 armor pen and the active grants 20% movement speed and 40% attack speed for 6 seconds.

R > W > Q > E. You're entirely auto attack based so you'll want to focus on that. Maxing Tumble gives more stealth during Final Hour but less damage overall. Your trades will be better with Silver Bolts maxed. Maxing Condemn first or second is pretty useless since it isn't activated all the time.

Night hunter
Vayne's passive gives you a bunch of free movement speed when chasing. The bonus gets a lot stronger when you use Final Hour, which is what lets you chase for kills and reposition more quickly in team fights.

Tumble
This is your main ability. You'll want to use this to get that little bit of range for your auto attack, dodge an ability, activate your stealth, anything basically! You can't go over walls with this!


Silver bolts
Your main damaging ability. It activates after every 3rd auto attack in a row on the same target. This can also be activated with your Condemn. Condemn should give you two stacks of Silver Bolts which is massive damage.


Condemn
This is your wall-crash. You slam people into walls and unload your damage into them. This can also be used as an interrupt for most gap-closers if timed well. You should be looking to use this anytime you see the enemy near the wall. Doesn't matter what else you're doing. Stop, drop, and wall-crash it up.


Final hour
This is your damage steroid for that extra overall power you need to kill somebody. Use this at the start of any duel and try to use your Tumble while in this. If you achieve a wall-crash during this do NOT use your Tumble for the duration of the stun. The main use of your Tumble is to cancel the enemies' auto-attacks, start up your next auto, and make the enemy guess where you are. With every Tumble you should be changing direction to disorient your enemy.