Alistar is really annoying as his cooldowns are just too low and his sustain and tankiness are too high. Make sure not to stand ontop of your ADC as he will stun both of you, and use your E when he's running you or your ADC down. Taking sweeper and gaining bush control is really important into him as he cannot W you if he cannot see you. Also focus on the ADC matchup as that usually dictates whether this is winnable or not.
Amumu
Take Fleet and gain vision in lane bushes. This is all about mechanics and whether he is synergized with his ADC. He is like Leona in the way you can E him to prevent him from getting close to you, but unlike Leona his skillshot stuns you instantly so you have to buffer E before you get hit. If he R's you and his ADC is a Miss Fortune or Ezreal or similar, then it's just straight up over. Ban or dodge depending on his ADC honestly.
Leona
Leona players aren't very smart and will most likely target you. If you get hit by her impale, just E her and time it so your E connects with her the moment her character starts dashing towards you. The impale itself is only a root so you can E while she is dashing. Do this correctly and you avoid her stun while she will be miles away from you. If she is dumb enough to ult you, just dodge with Q and then E her the same way.
Anivia
Just move to one direction and Q in the opposite direction to fuck with her. Sometimes switch it up and move in an intentionally telegraphed and predictable way instead to even further fuck with her. All you gotta do is juke her Q and she is useless. For her R you just E her before it grows to full size and she will be unable to enhance her E and she won't deal damage.
Ashe
AHAHAHAHAHXXDXDXDDXDXDXDAHAH
Bard
This matchup is such a wild card because it depends on how good the Bard is. If he's bad you just steamroll him, but if he's good his main strength will be coordinating ganks with his portals to abuse your lackluster peel. Avoid shoving mindlessly because he will let you, and it's what he wants. Against a good Bard it will almost always lead to getting portal flanked and ganked. Additionally he can heal the ADC to negate your poke which Vayne dislikes. He has point n click slow which Vayne also dislikes and he doesn't need to care about your lane pressure that much.
Blitzcrank
He should be in minor honestly but I'll put him in even purely because one mistake is all it takes for the lane to get sort of out of hand. If he flash E's you he loses if you and your ally focus the enemy ADC, but if he's ahead it will just lead to you getting oneshot usually. With that said, you really shouldn't get hooked by this guy. Prioritize good bush control on lane and poke well across the wave. Stand in your casters and Q into your melee minions then walk back after a single AA. If you shove a hook champion in then you will always have minions to hide behind.
Brand
It's a skill matchup but Brand favored due to wave clear. You win in raw damage since you should dodge all his skills with ease because you're Vayne. His E will splash from the wave and poke you so Fleet - Second Wind and get an early refillable potion aswell if necessary.
Braum
Braum is annoying but all he does is prevent you from flashing for kills and from generally committing and extending a trade. If you play this build patiently as you should be doing anyway then he's not as annoying as you might think. Yes your W true damage is not reduced by his shield, and no you should not max it for that reason.
Galio
Only use Q aggressively when his abilities are on cooldown as he has a lot of tools to punish you for it. You can use your E to cancel his dash but you can sometimes get hit and end up cancelling his taunt charge up which will end up knocking you up, taunting you after and giving Galio a free escape. Just be quick with E and stay in max range of his dash so this won't happen.
Gragas
Focus on spacing and dodging his skills. Respect his R if he's good.
Vayne Support inspired by Woahokaybuddy
Build Guide By Fenreee
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