The world is not always as civilized as people might think. There are still those who would follow the blackest paths of magic and become corrupted by the darker powers that flow through Runeterra. Shauna Vayne knows this fact well. As a young privileged girl in the heart of Demacia's elite, her father tried to convince her of the constabulary's ever-vigilant eye. Young and nave, she truly believed that her world was one of perfect safety, until one night, when a twisted witch took interest in her father. The malevolent woman overcame her father's conciliar guard, then tortured her family before murdering them. The young Shauna escaped only by hiding herself and then fleeing once the hag had departed, plagued by the screams of her loved ones as she ran. A burning hatred was born in her that day, one that could never be denied.

Vayne was able to take care of herself using her father's money, and she began to train as soon as an instructor would have her as a student. By the time she was a fully grown woman, she had become a grim warrior. However, the fields of battle were not to be her home. Demacia needed a protector, one who hunted those lost to the darkness. Shauna used her family's contacts to become the first Night Hunter, and now her prowess is the stuff of legends. It is said that those who practice the black arts quake when they hear that the Night Hunter is on the prowl. Despite her crusade, Shauna has looked at the League of Legends in horror. There are champions who have clearly lost themselves to the blackest of magics, and who have been embraced within the League even though they should be put down for the safety of all. The time has come for the Night Hunter to execute her secret mission � to purge the League of Legends.

Not all shadows are to be feared. At least, if Vayne has her way.

Pros:

Good Damage
She is hard to get away from
Silver Bolts make it easy to kill tanky dps
She is very good at ganking(Ult-->tumble-->condemn into wall-->An Enemy Has Been Slain)

Cons:

Vulnerable to cc
You have to have good positioning to get your stun off
She is very squishy

Greater Mark of DesolationGreater Mark of Desolation: Standard dps runes for most damage output.

Greater Quintessence of DesolationGreater Quint of Desolation: The more armor pen the better.

Greater Seal of Malice: The more attack speed you have the more you proc your silver bolts.

Greater Glyph of Alacrity: The more you crit the more damage you do especially if you have an Infinity Edge.

21/0/9 are the basic masteries for a dps champion.

21 Offense: Gives you the best damage output for Vayne.
0 Offense: You don't need these because you are not a tank.
9 Utility: Makes ghost better as well as improves exp gain and duration of neutral buffs.

If you don't usually get the neutral buffs you can take that talent out and put it in the last point of sorcery to make your cooldowns a little shorter.

I like to use both Ghost and Flash. If u need to use one of them to help you get a kill you still have the other to help you escape if need be.

Exhaust is another summoner spell that is helpful on 1v1 fights as well as slowing them so you can escape.

Cleanse is also helpful because if u get stunned there is a good chance you will die because she is really squishy.

If you feel like u need a little more damage you can always go with Ignite to help you get a kill.

Tumble is her best move in my opinion, it gives her great bonus damage on her attack as well as resets her attack to give her great burst if you time it with your third attack and can help you chase down almost every hero because it only has a 2 second cooldown.

Silver Bolts gives you the ability to do a good amount of damage every third attack especially on tanky dps.

Condemn does good damage but is not very helpful unless there is a wall that you can hit them into otherwise it will knock them back and give them a chance to get away.

Final Hour is a very useful ultimate it gives her a bonus 160 movespeed while facing an enemy, gives her a 1.5 second stealth and increases her base attack damage.

Doran's Blade is a very good starting item as it gives you health lifesteal and damage which can give you an edge in 1v1 fight early game. You can also start with just Boots but you don't really need it at level 1 because your passive is pretty much built in boots and without the bonus health from the Dorans Blade you would be very very squishy early on.

Berserker Greaves are a must since the bonus attack speed makes it easier to get your silver bolts proc and gives you the best damage output.

Bloodthister/ Black Cleaver you can get these two in any order but they should definitely be your first and second items after boots because they give you great damage and the lifesteal could be the reason you win in a 1v1 fight. In my opinion you should not get Trinity Force, it may be good early game but late game it does not scale as well as Bloodthirster or Black Cleaver.

If you think you need a little more survivability you can always get a 2nd before you finish of your Bloodthirster or Black Cleaver.

Frozen Mallet/ Phantom Dancer give you decent bonus damage but the main thing is that they give you more survivability. The bonus health and movespeed will make it a lot harder to catch you but also make you more able to chase people down.

Infinity Edge gives you great damage especially with the bonus crit from phantom dancer.

If you think you need more health or survivability I would suggest you switch infinity edge for a banshees veil. As well if they have a tanky dps team you could go a Madred's Bloodrazor to help shred their hp. If you have an AD heavy team a Last Whisper could also help if they are stacking armor.

Vayne works very well with teammates that have either a stun, snare or knock up so that they give her more time to attack them but it also gives her more time to set up a Condemn into a wall because it is not always easy to knock the enemy into the wall while they are running.

It is very easy to farm as Vayne. She has good starting damage and attack speed as well as the proc from silver bolts gives you a better chance of getting auto attack creep kills(if you don't feel like last hitting). You should also try to always get your neutral buffs so that you can chase people down easier with the slow, mana regen and cooldown reduction.

Vayne is a very good range dps that if played right can carry games almost by herself. She has great burst as well as great auto attacks. She is a very good ganker and farmer, but she is also very squishy and can be shutdown by 1 or 2 stuns so be careful.