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she is an early game all-in champion. She can land her E while you are stuck in your AA animation while getting a mist. Just permaban her and you'll be fine.
Nautilus
Same thing as Leona, except that at level 6 he has a point-and-click knock up that will lead to a guaranteed kill. Try to hide in your E and dodge the hook and you'll be fine (you can also permaban him. i still recommend Leona though)
Pyke
This champion is very op. Ward the lane bushes so he can't deny your poke, or land an easy hook. 1 hook = 1 death, so be carefull. you can't win him in an early 1v1.
Pyke is a difficult champion, so if you realize that your enemy is somewhat new to the champion, you can make his laning fase a nightmare ;)
Thresh
Thresh's hook is slow ,but unpredictable. Stay away from his E range, dodge his Q's and you'll be fine. If you are a good Senna, and player overall, i recomend always going for the grasp build against Thresh, because if you win the special event, thresh's souls will be better.
Blitzcrank
Easiest hook matchup. it is very easy to bait one of his Q's. Get the most value out of his long early CDs. But don't get too cheesy, if he lands a Q you will probably die.
Alistar
you can poke him very hard at the start of the match, because he isn't a champion 'till level 2-3. Later on you can avoid his normal engage with your E.
Bard
use your E to become invulnerable to his meeps.
If you react fast, you can E just before getting stunned. Now Bard has 2 choices: doing nothing, because he can't hit his AA (neither the ADC), or getting close to be able to attack, and end up poorly posisionated.
Brand
He has better damage and range in laning fase, and you can just E his R, nothing else (he can still R a minion a hope to bounce on you).
Try to bait his abilities in order to get him out of mana. Try to get a mist on him by Qing a minion and using your extra movement speed to hit your AA.
Braum
He can't protect his ADC from your AA's, so getting mists is very easy on this match up. if he hits his Q, use your E instantly in order to not get stunned by any AA. (Be careful, he can block your ultimate),
Janna
Always start farming your passive with her, if she's scared of your damage, she will shield herself, leaving the ADC helpless to your next poke. If she is trying to engage on you, use your E to dodge enemy ADC AA's.
Karma
She's pretty annoying, so stay calm. Stay behind minions when she tries to poke (not too close, because her Q is an AoE ability). Don't be too scared because you will out-poke her very quickly.
Lulu
[NOT ENOUGH DATA]
You shouldn't have that much of a problem when facing Lulu. her poke isn't something to fear. Unless his paired with a high damage early ADC.
Try to protect polymorphed allies with your E
Lux
Use your E when you see that you're getting stunned. Try to hit her with a W when she's playing agressive.
Morgana
How you use your W is everything in this matchup. Try to kill a minion with your root to have less chances of getting black shielded. If you W Morgana, or someone close to her, she can only black shield one of them, so target the other.
Nami
She hits harder than it looks. if you're at full HP, try to Q after her W in order to mitigate some of the damage. try to E when about to get stunned. Your E give allies some Movement Speed, so use that to dodge Nami's R with ease.
Rakan
He is very slippery. so don't expect to hit a lot of W's on him. Be careful of his long range engage, if he catches you in teamfights, and you don't have flash, use your R (only when you see a chance of winning the TF) before getting knocked up.
If he plays to agressive on laning fase, try to hit him with a W when retreating with his E to root both of them (or to make him use his W defensively.)
Sona
She hits harder than it looks. try to bait her Q to then poke. try to E before her R. In late game, your W and R will be more effective because players tend to be close to Sona.
Soraka
She hits harder than it looks. You can poke her very easy if you play careful enough. try to use E before her E because you will be in a very bad spot when trading without it. If Edge of Night isn't that necessary, build Executioner first.
Swain
[NOT ENOUGH DATA] Don't give him too many souls. You can use your E to escape from his R more easily, other than that you shold be fine
Tahm Kench
[NOT ENOUGH DATA] you can farm mists on him pretty easy. If he lands a Q to engage, Use your E to make his slow useless for a couple of seconds. After that he wants to AA you, so landing your W will be almost guaranteed.
Taric
[NOT ENOUGH DATA] His E has a very bad range, so if he wants to engage, use your W.
On teamfights, try to use your R before him, to make full use of it.
Vel'Koz
Easiest poke matchup. Stay behind minions and you'll be fine. If you are scared of him, you can always get your mists with Q to make it faster.
Xerath
One of the hardest poke matchups. He can make farming your passive a nightmare. You can't E out of any of his abilities. If he has mana, don't poke as often, just grab mists from the ground with a Q (extended with your minions)
Yuumi
The champion itself isn't annoying (at least in laning fase), but will make farming your passive VERY slow with her W. If she gets off her ADC, try to hit her with a W, if she W back, she will root her ADC, and if not, Yuumi will get stunned. If Edge of Night isn't that necessary, build Executioner first.
Zyra
HARDEST poke matchup. She can Q-E you while getting a mist. Because your health is too low, you can't risk it and try to walk on her passive, so you just have to play VERY safe. If she has mana, don't poke as often, just grab mists from the ground with a Q
Varus
(This is for Comet Lethality Varus. On-hit varus is somewhat like Kog'Maw) One of the hardest ADC matchups. He can poke you very easily. Bait his abilities to then poke.
Jhin
One of the hardest ADC matchups. He has very long range so, with the correct Support, he can make your laning fase a nightmate. While you grab a mist, he can always land an AA on you, so be careful when he has the 4th shot.
Aphelios
OP champ. He can AA you with Calibrum (the green weapon) while getting a mist. Abuse your range when he doesn't have Calibrum.
Ashe
When she wants to all-in, use your E to make her useless. try to E before getting stunned by her R. Stay behind minions to dodge her W.
Caitlyn
She can land an empowered AA while you grab a mist. She can also poke you with her Q. If an Ally has low health, retreat with E to make it impossible to her to shot R. If she's a good Caitlyn, she can put traps on very annoying places, so be careful with that.
Draven
She can land an empowered AA while you grab a mist. Try to aim your W's to where his axe's are landing.
Ezreal
OP champ. if he wants, he can play extremely safe, making it almost impossible to farm your passive. Abuse his long E cooldown.
Jinx
Not that much of a threat. Use your E to hide ally champions when getting stunned by Jinx's E. When trading, dodge her W and you'll be fine.
Kai'Sa
Don't let her proc her passive on long trades. If she hits her W, you can't do anything to stop his Ult follow up. If she has Hail of Blades, make her proc it to then retreat, after that you can trade safely.
Malphite
Abuse his early game by Qing him after his Q, that way you will mitigate some damage while getting mists. After level 6 you need to be careful with his engage, always be ready to flash. If you don't have flash up try to R before getting CC'd.
Pantheon
[NOT ENOUGH DATA] Abuse his melee range and poor engage. As long as you keep the distance, you should be fine.
Sett
Abuse his melee range and poor engage. Keep bushes warded to dodge his HexFlash. When trading, his W will charge super fast, so be ready to dodge the true damage nuke.
Zilean
Your E will be very important in this matchup, because you can deny additional damage from his double Q engage, and you can dodge his E very easily. Bait his Q and you'll be fine. In teamfights, focus him in order to "waste" his ult on himself.
Kalista
[NOT ENOUGH DATA] She can dodge your W very easily with her Passive. You can stop her from moving arround with your E. Try to R while getting knocked up with her R.
Kog'Maw
Abuse his terrible early game. You can stop his W with your E. Remember that your E gives movement speed to allies within it, so try to use it to save an ally from Kog'maw's passive.
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