ya es good on everyone
Thanks to TRUeLM, Plastictree, Scrax, Xiaowiriamu, foggy12, JahGFX, jhoijhoi, msrobinson, JEFFY40HANDS, Nyoike, MissMaw, and me :) for the sigs!
I should probably try this, especially since my left mouse button is ****ped out anyway and I often have to click two or three times before it counts. :P
Off the top of my head, there are these abilities that should never be smart cast:
Enchanted Crystal Arrow
Crescendo
The Equalizer



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Smartcasting on combo champs like Akali, LeBlanc or Ryze boosts your burst by a LOT because you are able to get four spells off in the time of one.
To change your bindings to smartcasting, press ESC ingame, >Key Bindings>Bind smart cast spell 1-4 to Q -R and summoner spell 1 and 2 to D and F.
I just started using it on Akali(She's the only AP I play) and it makes her gameplay so much more responsive and fluent, it's wonderful. You also get all your four spells including shroud off in a blink of a second, that gave me a doublekill at my tower when I got dived, huehue.
Just try it, you will love it.