These are the ones I recommend.
Greater Mark of Magic Penetration are irreplaceable.
Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.
Greater Seal of Scaling Mana Regeneration for full-AP casters. Use these if you aren't building mana regen.
Greater Glyph of Cooldown Reduction for flat CDR. Pretty standard.
Greater Glyph of Scaling Ability Power for some AP by mid-late game. Nice on some casters.
Greater Quintessence of Ability Power are good for general early game power.
Greater Quintessence of Magic Penetration can be nice for flat-pen stackers like
Fiddlesticks.
Greater Quintessence of Health great on all champions, gives nice survivability.

Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.








Thanks to Jovy for the sig!
subject to scrutiny by the rune man:
- I sometimes like to take 1
Greater Quintessence of Movement Speed on my casters, because it's hard to itemize for move speed on casters (on generic AD carries, I can just get PD).
Greater Glyph of Cooldown Reduction will make it VERY easy to itemize for high CDR (with runes/masteries, you'll be able to get ~30-35% CDR with only one item). However,
Greater Glyph of Scaling Ability Power will probably make you a dominating mother f***er in lane.
A mix of flat and scaling mp5 seals can give you the best of both worlds.
- I sometimes like to take 1



A mix of flat and scaling mp5 seals can give you the best of both worlds.
PsiGuard wrote:

Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.



Pretty much. AP/lvl glyphs are more standard than CDR though.
As for quints:
AP quints are standard and best for 90% of all AP champions.
HP quints work, but AP is pretty much always better.
Quoted:


Haha, heck no.
Doesn't matter.
MrP quints are only good on champions with BAD AP ratios. That would be below 0.23 per 100 flat damage on a spell.

NicknameMy wrote:
Well, da_neo uses


Nope.
He doen't prove ****. He makes bad comparisons with bad rune combos.
You're obviously not thinking when looking at his graphs --.--
"You can't have your privacy violated if you don't know your privacy is violated." - Mike Rogers, U.S. Representative for Michigan's 8th congressional district, 2013
I.e: Mike Rogers doesn't think it's rape unless the victim knows (s)he has been raped. Sounds legit.
I.e: Mike Rogers doesn't think it's rape unless the victim knows (s)he has been raped. Sounds legit.
PotatisFarfar wrote:
Ap/lvl seals? So good!
Work on some casters, but are generally worse than mana-reg.
Far from standard in any case.
"I walked up to her big butt and asked her *** butt what." - Lil Wayne, lyrical genius
"I can't decide where I stand on abortion, on one hand it is killing children, on the other it gives women a choice." - ???
"I can't decide where I stand on abortion, on one hand it is killing children, on the other it gives women a choice." - ???
PsiGuard wrote:
These are the ones I recommend.

Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.







^
Basically what Psi said. I'd advise getting Flat AP or Health Quints.
You need to log in before commenting.
But now i know it's time to get runes for casters
Now i know
i need
Magic Pen Red
Mana regen Yellow (which is better flat or justper lvl)
I was thinking about magic pen blues? (or maybe AP)
ANd quints i don't even know
Guys this is for ALL MANA AP casters
Malz
Annie
Cassiopea
Kass
AND ap NUKERS in general
Viegar ETC