These are the ones I recommend.
Greater Mark of Magic Penetration are irreplaceable.
Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.
Greater Seal of Scaling Mana Regeneration for full-AP casters. Use these if you aren't building mana regen.
Greater Glyph of Cooldown Reduction for flat CDR. Pretty standard.
Greater Glyph of Scaling Ability Power for some AP by mid-late game. Nice on some casters.
Greater Quintessence of Ability Power are good for general early game power.
Greater Quintessence of Magic Penetration can be nice for flat-pen stackers like
Fiddlesticks.
Greater Quintessence of Health great on all champions, gives nice survivability.

Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.








Thanks to Janitsu for the sig!
subject to scrutiny by the rune man:
- I sometimes like to take 1
Greater Quintessence of Movement Speed on my casters, because it's hard to itemize for move speed on casters (on generic AD carries, I can just get PD).
Greater Glyph of Cooldown Reduction will make it VERY easy to itemize for high CDR (with runes/masteries, you'll be able to get ~30-35% CDR with only one item). However,
Greater Glyph of Scaling Ability Power will probably make you a dominating mother f***er in lane.
A mix of flat and scaling mp5 seals can give you the best of both worlds.
- I sometimes like to take 1



A mix of flat and scaling mp5 seals can give you the best of both worlds.
PsiGuard wrote:

Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.



Pretty much. AP/lvl glyphs are more standard than CDR though.
As for quints:
AP quints are standard and best for 90% of all AP champions.
HP quints work, but AP is pretty much always better.
Quoted:


Haha, heck no.
Doesn't matter.
MrP quints are only good on champions with BAD AP ratios. That would be below 0.23 per 100 flat damage on a spell.
"I'm ebolakin. You can refer to me as Ebola-Chan." - Vurtax
"I also am Otherkin. Whenever autumn rolls around I can feel my kin-type slowly taking over my body. You must know, I identify as pumpkin. I can control it pretty good most of the time, but when September ends, I just cant hold it in anymore. Whenever Im outside I see my brothers and sisters being chopped into soup, coffee, donuts, cake, drinks, bread - ppl even cut human faces into their skin, making a mockery out of their noble appearance. When I see things like that I cant control my pumpkin urges anymore. My natural instincts kick in. I then sit down motionless, while getting bright orange." - Morgana L
"I also am Otherkin. Whenever autumn rolls around I can feel my kin-type slowly taking over my body. You must know, I identify as pumpkin. I can control it pretty good most of the time, but when September ends, I just cant hold it in anymore. Whenever Im outside I see my brothers and sisters being chopped into soup, coffee, donuts, cake, drinks, bread - ppl even cut human faces into their skin, making a mockery out of their noble appearance. When I see things like that I cant control my pumpkin urges anymore. My natural instincts kick in. I then sit down motionless, while getting bright orange." - Morgana L
NicknameMy wrote:
Well, da_neo uses


Nope.
He doen't prove ****. He makes bad comparisons with bad rune combos.
You're obviously not thinking when looking at his graphs --.--
"Doing something, almost being done, then parents come in and don't let you finish.
Yes, I had a rough childhood." - devdevil
Yes, I had a rough childhood." - devdevil
PotatisFarfar wrote:
Ap/lvl seals? So good!
Work on some casters, but are generally worse than mana-reg.
Far from standard in any case.
"Blizzard spoke thus; Thou shalt not BM. And the players replied Nay, I shall Play my hand with Lethal already on the board. And so Blizzard sent unto them this Brawl of Yogg, As a lesson for their sins of Pride and Greed, for he is the Prophet of Madness and RNG. On that day, the tavern descended into an era of chaos and darkness, until the weekend passed and everyone forgot all about it. Amen. Book of SMOrc, Verse 20, Chapter 4." - Feam T
PsiGuard wrote:
These are the ones I recommend.

Greater Seal of Replenishment for an early game boost (for casters that build some mana regen quickly). You'll probably want these.







^
Basically what Psi said. I'd advise getting Flat AP or Health Quints.
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But now i know it's time to get runes for casters
Now i know
i need
Magic Pen Red
Mana regen Yellow (which is better flat or justper lvl)
I was thinking about magic pen blues? (or maybe AP)
ANd quints i don't even know
Guys this is for ALL MANA AP casters
Malz
Annie
Cassiopea
Kass
AND ap NUKERS in general
Viegar ETC