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Long range root could hit Senna, and as Senna is squishy, this is risky for her. Also, as Senna's W doesn't activate immediately, it is very easy for Morgana to black shield it.
Pyke
Fairly easy for pyke to hook and stun senna, and he can dodge her abilities. Also as Senna has no burst, it is very difficult for her to kill Pyke due to his passive
Rengar
If rengar gets fed, he can completely shut down Senna's game with almost no counterplay.
Kayn
Kayn (specifically blue Kayn) has lots of potential to get to Senna in the backline and kill her, and he can also dodge her abilities fairly easy due to his E.
Shaco
Shaco can come out of nowhere and one shot Senna very quickly.
Zed
It is dangerous as there is lots of opportunity for Zed to dodge Senna's W. However, there is opportunity for Senna to heal before the Zed's ult pops, so it is possible to survive.
Ashe
Ashe and Senna have great poke ability, and there is practically no way they can run away from this combo.
Caitlyn
Senna and Caitlyn have some of the best range out of any botlane, making them almost untouchable. Also, Caitlyn can normally get a free trap and/or E when Senna hits her root.
Varus
Varus and Senna can poke quite well together.
Ezreal
Senna and Ezreal make for a good poke/safe late game scaling duo.
Tahm Kench
Look up fasting Senna if you haven't already...
Synergies
IdealStrongOkLowNone
Ashe
Ashe and Senna have great poke ability, and there is practically no way they can run away from this combo.
Caitlyn
Senna and Caitlyn have some of the best range out of any botlane, making them almost untouchable. Also, Caitlyn can normally get a free trap and/or E when Senna hits her root.
Varus
Varus and Senna can poke quite well together.
Ezreal
Senna and Ezreal make for a good poke/safe late game scaling duo.
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