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Runes:
Precision
Inspiration
+10% Attack Speed
+9 Adaptive (5.4 AD or 9 AP)
+6 Armor
Spells:
Flash
Heal
Items
Ability Order
Night Hunter (PASSIVE)
Vayne Passive Ability
Threats & Synergies
Threats
Synergies
Extreme
Major
Even
Minor
Tiny
Show All
None
Low
Ok
Strong
Ideal
Extreme Threats
Ideal Synergies
Caitlyn
Yuumi
Synergies
Ideal
Strong
Ok
Low
None
Yuumi
Champion Build Guide
Early Game
Early game Vayne might sound bad, but it's not horrible. Using press the attack(rune) while at the same time leveling you W first, you have a LOT of damage. With an aggro support you can do massive damage as long as he engages for you, if not use your e and trade. Using autos with PTA is also great poke. Try to poke enemies down early and at lvl 6 have support engage or hit condemn, and you should be golden for a kill. Mid game you are also strong, but not too strong yet. You can't poke as much because most champs already have their item power spike after laning. Wait for an engage or play for picks and get fed to enter the late game
Late game
Getting one pick can get you a penta. You shred tanks, and squishies. Try to sidestep with your q when engaging alone after a pick, and target the enemy adc or if they have a nasus, go for nasus. If you can't do this wait for your team to engage, and after that first pick you are golden.
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