This is my take on Annie.
I have been having some success recently with scores that look an awful lot like this (ty hec for helping me turn that game around. varus got 11 kills in the first 7 mins. then well)

I dont know a lot about runes. if anyone happens to read this and can help me out please do so

Reds

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Magic pen runes should be self explanatory to an extent.




Yellows/Blues

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I love flat AP runes. they really help with damage output at the BEGINNING of the game, hopefully giving the summoner the chance to get a kill or two.



Quints

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Flat AP runes a norm for ap champs.

Pyromania

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After Annie casts 4 spells her next one stuns! once Annie has her stun if you can use it on an enemy champ go ahead otherwise just carry on farming with Disintegrate and Incinerate



Disintegrate

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This is the spell I would level up first. It is very easy to kill minions with, disintegrate also refunds the mana you expended if you kill the minion with it



Incinerate

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this ability I get second. Incinerate is great for catching a group of enemies in a stun, or farming minions since it gets much stronger per level than Disintegrate so its worth leveling up all the way before Disintegrate if you wish.


Molten Shield

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This is a spell that you should level at 4. it can block a decent amount of damage, and dish some back if they autoattack you. plus you can use it to ready your stun.



Summon: Tibbers

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Tibbers is Annie's flaming bear! you can use him to nuke the enemies health, he also causes damage to anything near him. its best to get their health down a bit so you can try to kill them cleanly with just summoning him. you can just Ignite an enemy if tibbers does not finish them.

Ill try to explain here why I picked certain items for my build

Spawn

Boots and Health pots not much to say here

Early Game

I pick up morellonomicon first mainly for the cooldown reduction and mana regeneration. It also inflicts grievous wounds, lowering their healing regeneration rate by 50%. boots are probably obvious Annie needs mobility to play games! Tear of the goddess is a prereq for Archangel's Staff more mana regeneration and a sweet passive (each time you spend mana you get +4 to max manna up to 750)

Core

Archangels staff is the next item i suggest because it gives you +60 AP and its passive grants you 3% of your mana as AP. next is wooglets. you gain a little armor 100 ap and it increases your AP by 25%. Sorcerers shoes for more speed and magic pen. then add the unholy grail for more cooldown and mana regen.

Finish

the void staff adds more ap and a large chunk of penetration. if its going well or you are getting lots of assists maybe pick up Mejai's Soulstealer

Thanks to

jhoijhoi

for your wonderful guide to make a guide. (mine has a long way to go!)

1000Lava

your guide helped me understand Annie much better, I also used a bit of your formatting

9/14/2013

-Guide Created

11/21/2013

-Guide Updated for S4 Preseason will be subject to serious tuning.
-Updated Masteries

minor item changes

-Added trinket Stealth Ward
-switched Void Staff Zhonya's Hourglass
-Added Blackfire Torch