Lulu

This is Pyke's biggest counter. If Lulu saves her polymorph for whenever you engage, she can completely stop you from doing anything in team fights since the ability is point and click. I recommend banning every game you plan to pick Pyke.

Morgana

Since Morgana tends to rush Zhonya's Hourglass as her first-second item, she can save it to counter your ultimate. Her Q and ultimate are also very good at stopping Pyke from engaging as the stuns and roots last 3 seconds (without tenacity). Morgana's E also saves her and her teammates from any chance of Pyke hooking or stunning them during fights.

Zyra

Zyra has good poke in laning phase against Pyke, allowing her to widdle him down and kill him with a good E+Ignite combo paired with her ADC. She can also build Zhonya's Hourglass to negate Pyke's ultimate execute and reset. Despite this, she has little to no mobility and is extremely squishy. If she misses her E pre level 6, use that time to engage on her as she lost all of her CC and has no way of running away without using a summoner spell or being saved by her team.

Yuumi

Yuumi isn't much of a threat to Pyke as she is just annoying to play against as Pyke. Since she can't be hooked or stunned while on her allies, Pyke loses out on a lot of potential kill power on her and the ally she's attached to due to her passive giving them a shield and her E being able to heal them. Her ultimate is also really good against Pyke. The reason she's a minor threat, though, is because laning phase is very difficult for Yuumi when she wants to get her passive. If you see Yuumi walking up to auto attack you for a shield, engage on her. If she hops to her ally immediately, turn on her ally. Yuumi is also extremely squishy, has no mobility, and rarely builds Flash or Zhonya's Hourglass, allowing Pyke to chase her, one shot her, and get an easy reset on his ultimate when she is alone. One other thing that makes Yuumi pretty weak against Pyke is the lack of vision she can place. Since she's so squishy, she relies on allies to bring her everywhere she goes, meaning she can only ward where her allies go. Use this as an opportunity to sit in a bush and take her and her allies out when you know they're going to try warding.

Nami

Nami's Q can stop Pyke in his tracks while he is trying to hook. Since Pyke loses movement speed while he is charging his Q, she can hit him easier with her Q, stopping it completely. She also has a bit of movement speed for her and her allies which make it harder for Pyke to hit his abilities.

Soraka

If Soraka saves her E until Pyke begins charging his Q, she can stop him completely with the quick silence. It also stops Pyke from using his E to engage for a short time. Soraka's ultimate can save both her and her teammates from his ultimate easily, but she has little to no mobility throughout the game, allowing for an easy kill if she's separated from her team or mispositioned.

Taric

Taric's E can stop Pyke from engaging in fights and his Q can heal him and his allies a bit which may deny Pyke kills, although the biggest threat is the invulnerability from his ultimate that completely counters Pyke's ultimate and denies him resets.

Zilean

Zilean's Q+Q combo can stop Pyke dead in his tracks when he tries to engage, and the slow on his E can slow him down further, denying a lot of engage potential. Plus the amount of poke Zilean has against a squishy champion like Pyke can cause major issues in lane. But the worst part is his ultimate which can save allies from death and deny Pyke ultimate resets.

Renata Glasc

Renata's ultimate isn't very effective on Pyke, but her Q can deny engage and help her escape and her W can save her and her allies from his ultimate, so be sure to bait it out before going all-in. Don't ult an enemy who has Renata's W unless they're the last one alive on their team (or part of the last 2 alive).

Alistar

Alistar's all-in potential and CC removal on his R makes him a big threat to Pyke in both the early and later game.

Rell

Another one of Pyke's bigger counters, Rell is able to stop his engage and completely turn fights around in the press of a button. Due to her high health and armor (if she builds it), Pyke is also unable to do much damage to her on his own. The only thing that Pyke can do is bait out her W and let his team do all the damage as she tries to waddle away.

Amumu

Amumu is pretty strong against Pyke as his Q+R combo is able to quickly deny Pyke of any mobility and engage.

Bard

Since Bard tends to roam a lot, just as Pyke does, bot lane will be a 1v1 lane around the 8 minute mark. Bard's ultimate can save him and his allies from Pyke's ultimate, but since the cast time is really low, if you have a quick enough reaction time, you shouldn't miss your ultimate to Bard's R. Just don't follow him through his portals (E) unless you know where all of his allies are and his Q is on cooldown.

Brand

Brand melts people, but can also be one shot pretty easily. Laning phase will be difficult as he can easily widdle you and your ADC down, but after laning phase, he should be easier to kill as long as you dodge his Q. Since Pyke has a lot of invisibility off of his W and Duskblade, he should be able to stop Brand from using his E and R on him, although if Pyke has already been hit by one of Brand's abilities, the enemy can see Pyke even when he is invisible.

Blitzcrank

As long as you or your ADC don't get hit by Blitzcrank's Q, laning phase should be easy, although Blitzcrank's E can completely negate Pyke's escape and engage, but can be played around if played well. Later on, Blitzcrank's R can stop Pyke from using his abilities for a moment and can cancel his Q charge if he's too close, so make sure to stay far away from him and focus on his allies in teamfights.

Braum

Braum is a very minor threat to Pyke, as his E is basically useless against Pyke. Braum is better at fighting against champions with poke such as Ezreal or Xerath, but not so much someone like Pyke. Just make sure you save your Q for the enemy ADC as Braum can dash to them whenever he likes which can allow for an easy bait and switch into his R if you miss your Q.

Fiddlesticks

As long as you go one or two tenacity runes, Fiddlesticks shouldn't be a big problem early game in lane. Since Fiddlesticks is also very squishy, he tends to rush Zhonya's Hourglass, so don't get baited by it when you decide to go in and try to execute him.

Karma

Karma is a very annoying champion to play against as Pyke. Since she has so much movement speed, shielding, and high damage poke, laning phase is nearly impossible for Pyke. Despite this, her mid-late game against Pyke isn't nearly as strong as long as you don't get targeted by her W in fights. Wait for opportunities to arise and go in when you know she doesn't have her W or R up.

Janna

Her Q and R can stop Pyke from engaging, but that's pretty much all she can do. Pre level 6, fighting Janna should be easy once her Q is down and engaging shouldn't be a problem as long as the enemy ADC doesn't have hard CC.

Leona

Leona is extremely tanky, even early game, and has a TON of CC, denying Pyke of any attempts to engage. Even if she doesn't target Pyke, it's still very difficult to kill her with her W and tanky items, making her a big threat both early and late game.

Lux

As long as you are able to dodge her Q effectively, then fighting her is a breeze, although laning phase against her is difficult due to her high damage poke and shields for both her and her ADC. Later game, she's an easy kill as long as you dodge her Q.

Maokai

Save your E for when Maokai engages on you and you can turn fights around easily. If he uses his full combo on you, just E away since his damage is so littler and Q him into your teammates if there are no minions in the way since he'll be on cooldown for a moment. Laning phase is really easy, but later game (after level 6) will become a bit more difficult due to his ultimate.

Nautilus

Nautilus is very strong against Pyke as he has a ton of cc and can deny Pyke of his escape if he decides to save his E. As long as you don't walk up too close to him, then it shouldn't be too difficult to get away unless he flash+auto attacks you, meaning you need to dash away and try to dodge his Q. If you're too far in a fight and he's level 6 or more, he can just press R on you and stop you from doing anything in a fight.

Pantheon

Pantheon has a lot of high damage in the early game and his E can block your ultimate execute, making him extremely dangerous in laning phase. Despite this, his late game is extremely weak and he'll usually fall off pretty hard (unless you're against Spearshot, but he doesn't play support so that shouldn't be an issue).

Poppy

Rakan

Senna

As long as you dodge her W, she's an easy kill due to her squishiness both early and late game. Just be aware of her attack range and don't let her poke you down by either playing safe and far away from her, or by playing super aggressive.

Seraphine

Seraphine's E and R can stop you from doing much in any fights, but since they're both skillshots and Pyke is a very mobile champion, if she misses, that's your queue to engage and kill her. If you aren't confident in your ability to dodge any of her CC abilities (and anyone else's for that matter), go tenacity runes.

Shaco

If you ignore Shaco in laning phase and team fights, he becomes useless no matter what items he builds. Just don't chase him anywhere when he hits level 6 or if he builds AP, as he can melt Pyke easily this way.

Sona

Sona's only CC ability is her ultimate. If you go tenacity runes, her stun duration is greatly decreased. Pyke destroys Sona in laning phase, especially if she gets too close. Abuse her in laning phase and get fed quickly off of her.

Swain

Since Swain tends to build Zhonya's Hourglass first or second item, he can stop Pyke from getting an execute with his ultimate. Also, Swain's ultimate gives him a lot of HP and steals the HP of you and your allies, making him pretty difficult to deal with levels 6 and up. His E is also very strong against Pyke as he can full combo him and deal a ton of damage in the blink of an eye with it. Pair this with an ADC and you'll die almost every single time he hits an E on you. Laning phase is hell against him, so roaming would be a good idea as long as him and his ADC don't hard shove the wave under your tower (which is what they should do).

Tahm Kench

Although Tahm Kench has a lot of CC with his Q slow/stun and his W knockup, he's pretty weak early game without his ultimate. Save your E when he hits level 6 so you can just dash away after he uses his R on you. His E is also very weak against Pyke as Pyke's ultimate ignores shields. If his healthbar is red, even if he has a shield that fills his health bar, you can still execute him easily. If you see him start to use his W, try to CC him out of it or away from your team when he emerges.

Thresh

Thresh can stop your engage pretty easily, but that's pretty much all he can do. Let your teammates break the walls of his R and just chase him down if you want to kill him. He has very low damage and his CC is not as strong against you as you may think. Just don't E onto him when he has his E up, as he can redirect your phantom and cause you to miss your stun easily. Don't charge your Q when you're near him, either, as his E can also stop your Q charge.

Vel'Koz

Once Vel'Koz uses his E, he doesn't have much escape against you. If he uses his E in a fight, use that as an opportunity to go in and kill him. Just be weary of the fact that although he is squishy, he can still build Zhonya's Hourglass which can stop your ultimate from executing him.

Xerath

Xerath's poke in lane paired with his high damage output with comet/first strike is pretty hard to deal with early game. Even mid-late game can be difficult since he can kill you easily after hitting his stun due to the fact that Pyke is so squishy. If you can hook him, he has no escape potential, so it should be easy to kill him if he's alone or you have your team with you.