This guide is a work in progress. I didn't like the Hybrid Fate builds out there so I built my own. I originally liked DPS Fate more than hybrid so I made my own hybrid that I enjoy even more than straight DPS. You will notice that I focus a lot of critical chance. This increases my damage greatly and frustrates my enemies as they don't expect to get so many crits during a 1v1 and lose.

5/5/2011: Added some Item suggestions, Added some notes to Skill Sequence
5/4/2011: Added Icons, Updated items section slightly and added some rune choices
5/3/2011: Started the Guide

I'm sure my masteries look a bit odd to some so let me explain. I did the math on Strength of Spirit and it just wasn't worth the 3 points to get around 13 hp/5 health regen. I used those 3 extra points to focus in on more damage. The best defense is a good offense is my train of thought.

You have some choices here based on personal taste.

Marks:
Greater Mark of Malice: I prefer early crits to armor penetration but this is a personal choice
Greater Mark of Desolation Greater Mark of Desolation

Seals:
Greater Seal of Vitality Greater Seal of Vitality: These are better than flat HP by level 5

Glyphs:
Greater Glyph of Warding: Use these to feel less squishy
Greater Glyph of Force: Use these for a more dps.
Greater Glyph of Celerity: This is an interesting choice. Lowering cooldowns helps all your damage.

I use magic resist because I feel very squishy early on, but if you feel confident you can always add ability power to really beef up your hybrid build

Quints:
Greater Quintessence of Fortitude: I use these personally to remove my squishiness
Greater Quintessence of Swiftness: I am trying 2 of these out with 1 Fort rune right now and liking the results, especially against Teemo or other mid characters who sometimes grab their boots first.
Greater Quintessence of Malice: More crit if you like
Greater Quintessence of Desolation Greater Quintessence of Desolation: More penetration if you like

My skill sequence is a bit different than other hybrid builds. I use Pick A Card mostly for it's utility until I just finished my Sheen so the proc can work with it. Before then I have lifesteal and attack speed so I boost that with Stacked Deck to increase how long I can stay in the lane and level Wild Cards to harass more effectively.

Another reason I put off leveling Pick A Card is that the base damage it adds per level is the worst of all his abilities.

I usually alternate Stacked Deck and Wild Cards. However, If I am mid lane and I am having trouble harassing, I will get 3 levels of Wild Cards before I go back to stacked deck to help me out. Change your sequence based on your opponents. I never take my first skill until I see who I am up against in the lane, in case an early stun might yield us first blood.

Here are some tips for using his abilities:

Destiny: Use this ability even for small jumps if it means a kill. The cooldown isn't that long don't be afraid to use this to get a single kill.

Also if the opposing team just scored an ace and they have an inhibitor and their 2 main turrets down, they will likely be pushing your base. As soon as you spawn buy Elixir of Fortitude and Elixir of Agility then port directly next to their nexus and burn it down. You should be able to burn down the nexus so fast they won't be able to do anything about it.

Be careful when using destiny to not just port to any random champion that might be alone. If you port to Warwick or Malphazar you might end up just getting destroyed and giving free kills to the opposing team.

I always start with the Vampiric Scepter unless I know I am going to be solo laning against a champ I will have trouble harassing. If that is the case then I start with a Doran's Blade for the extra survivability. If you do get the blade sell it when you run out of room for the next item.

Hextech Gunblade: Don't forget this has an active ability! This is great for the times in between those yellow cards to keep someone slowed.

Phantom Dancer: You can alternatively get another one of these instead of the 2nd gunblade. It will shoot your movement speed up and your crit over 100%. I have done this a few games when the lifesteal/spellvamp wasn't helping that much.

Infinity Edge: You may not finish this item since it goes above the average 15k gold you will get in a game, but that's okay. If you have all the other items you are still a beast who can teleport anywhere and gank anyone 1v1. If the game goes a bit long and you do pick this up, it's just silly what you can pull off.

Madred's Bloodrazer: This item looks really good. I am experimenting with putting this instead of the 2nd gunblade and will report back.

Other substitutions for last 2 items based on opponents build
Tons of armor: Black Cleaver is a great choice for reducing armor
You just need more lifesteal: Bloodthirster is a great choice and a quick trip through the jungle should get it stacked quick

Ghost: I always pick ghost because it is great for running away or catching up to stun. With the Phantom Dancer and Ghost you can catch up to even the fastest champions
Teleport: With 2 teleport abilities this allows you to be everywhere all the time. This really puts pressure on your opponents when they know you can effectively push 2 lanes back to back.

I know some people like Exhaust and/or Ignite but I find that my leveling wild cards early I can harass effectively without them.

In this build you have lots of lifesteal and spell vamp. If you are being attacked and think you might die, always and I mean ALWAYS be attacking something and casting wild cards. You would be surprised how many times this saves your life. You also have lots of critical damage which heals you for more than some might expect. I've won quite a few 1v1 fights that the opponent looked to be favored by simply attacking them and spamming stun as much as possible.

Get the Red Buff, esp if you are about to do some back door action. It's an excellent boost for you. Also make sure to use your red card when there are a lot of creeps in one general area.

When using this build in ranked play, you may have to modify your items AS NEEDED. Use common sense and buy magic resist when facing a 1.5k AP Karthus, more hp when needed, more armor when facing 4 Physical Damage based champions, etc. I also like to always have 2 wards in my inventory on every 1-2 trips back to the base. I ward liberally in the bushes in mid lane during early game and then in front of dragon/baron late game. If you catch them doing Baron you can always Destiny behind them and steal it. You need to have it warded to know when to use your Wild Cards for the last hit however.

If you are against Twitch or Evelynn you need to buy Vision Ward early game to prevent ganks. These are best placed in the middle of each lane to track movement and prevent surprises. Late game buy an Oracles Elixir every time you die, especially if there is an AP Teemo. Those Teemo mushrooms with that much AP destroy you since you are a very squishy champion.

Twisted Fate is an assassin. You never want to be in the middle of the team fight. In a big fight you want me to coming in to yellow card, throw some wild and a few auto attacks then pulling back and repeating. If you get focused you pretty much die. The lifesteal helps a bit but not enough to tank their whole force. And once they seem the damage coming out of you, you can bet they are going to focus you first next time.

Make sure you let your teammates know before you destiny in. I've had a few times where I'd destiny in to save someone and they would run away leaving me to deal with the 2 that were chasing them and you can guess what happened then.