Ahri

Ahri can be a handful to deal with, but you can dominate lane. Avoid being charmed and this lane is very easy. Make sure your ult is not interrupted, as last minute charms can cancel it.

Annie

I hate Annie. That long auto attack is a pain in the *** in lane. Anyways, she generally outbursts you pre-6, so unless you land a nice silence, you should avoid fighting. Post-6, she is still very dangerous, so be careful.

Akali

Generally the same as Katarina, but even weaker in lane. You own the lane, but you must be post-6. Your ult can shut down anything she throws at you, but she has 3 charges of her ult. Be sure to kill her the first time.

Brand

Anivia

Azir

Ezreal

Diana

Galio

Somebody picking Galio into you serves as a symbolic middle finger. He can mitigate much of your damage with his Bulwark and render you useless with his ult. However, your Q is a silence and can stop much of this pain and misery. You can usually kick his *** in the first few levels, but once he starts to stack MR, it's over. Shoving him under tower is your best bet, as he will have to use his Q to farm. His mana costs are atrocious, so this works into your favor. His Q is a massive nuke, but it is hard to hit, so dodging that will keep you alive. He has no kill potential until level 6, so until then, the lane is yours.

Gragas

Heimerdinger

Jayce

Karma

Karthus

Kassadin

Katarina

This matchup is laughable. Malzahar already ***** on melee champions with Malefic Visions spam. Katarina can virtually do nothing to stop you and your reign of terror. You can stop her ult with your Q and then proceed to ult and kill her. You should at some point get her low enough for the Malefic Visions-Ignite combo. However, if this moment never comes, go ahead and shove that hoe under tower. Katarina cannot farm under tower, and she also risks picking up the Space AIDS. In general, if you are constantly getting terrorized by Katarina in solo queue, your troubles are over.

Kayle

LeBlanc

If there was every a definition of bully the bully, this is it. LeBlanc can dodge your silence pre-6, and this is where she will be looking to kill you. Your best bet in this lane is to shove the wave in as much as possible and make her miss farm. Stay healthy; LeBlanc has insane burst potential. You should be fine as long as you stay away from her burst.

Lissandra

Lux

As if the laugh wasn't annoying enough, a good Lux will never miss an (E) Lucent Singularity. She also has the ability to cancel your ult with some good reflexes and can stay away from all your poke.

Morgana

Syndra

Ugh. Syndra has obnoxious range and waveclear, so do not shove her under tower as it will open yourself up to being ganked. Her stun will also wreck you, and she has way more burst than you. I recommend asking your jungler for help, as if she pushes hard she will be susceptible to ganks. Always be aware during your all-ins that she can easily turn it in her favor if you miss your silence or she has many balls and you are stunned.

Talon

This man is very dangerous, and you need to know that. Post-6 you can stop a lot of his burst, but pre-6 you must not miss a silence if he is trying to trade. It can mean the difference between life and death.

Twisted Fate

Viktor

Vel'Koz

Veigar

Veigar is deceptively easy to go up against in lane. Remember this though: later on in the game when you are rolling through everyone, Veigar will come out of the jungle and 100-0 you. Make sure he does not get out of lane with farm

Orianna

Nidalee

Xerath

Yasuo

Yasuo is a joke against Malzahar. As long as your stay away from his Q and the minion wave, he's no match for you. There's also nothing he can block, so make sure you kick his ***.

Zed

Ziggs

One of the most annoying champions to face in mid lane. Usually you

Zilean

Zyra

Gangplank

To whoever pick Gangplank into mid, **** YOU. Nothing like losing all your burst because of some damn oranges. Not much to say about this match-up, but if you ever see it, be aware that he can just waltz out of your ult.

Fizz

Fizz can cancel most of your damage if you mess up. A silence can cancel most of his abilities, especially that damn Trickster. When that is down, feel free to whale on him.