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Lee Sin is about as strong as kha'zix early game but scales much worse. Use your leap to dodge his Q and you should win duels against him. Lee sin will buy a sight stone and be able to take vision control from you but kha'zix is stronger once he gets some items so play it smart and don't let him snowball on you.
Rengar
Rengar is kha'zix's rival in the lore but the match up isn't too bad for him. Neither kha'zix nor rengar are super threatening early game with ganks and they both scale pretty well. Try to get deep wards against rengar once he has his ultimate so you can track him and warn your laners or counter gank when you think he's going to ult. Stay away from bushes when you're fighting him because he can leap out of bushes at you.
Vi
Vi is weak pre-6 so it's safe to pressure lanes without worrying too much about a counter gank. Just remember that vi can interrupt your leap with her Q or R so make sure to not use it right as she's hitting you with one of her spells.
Jarvan IV
Jarvan is strongest early game then falls off so the later the game goes, the better. Watch out when using your leap against him once he is level 6 because if you do it before his ult, he can trap you in.
Elise
Elise can be good against Kha'zix because she is stronger early game and less item reliant. Try to avoid fighting Elise until you have elder lizard. Use your W and smite to kill elise's spiderlings when she goes into spider form because that will lower her damage by a good amount. Kha'zix outscales Elise with items so try to not get let her set you behind. Build a hex drinker after elder lizard to ensure that you win fights against her
Nunu & Willump
Nunu is a jungle bully who will try to counter jungle you a lot early game. He's hard to fight and even harder to kill because of his snowball and ability to get an early quill coat. Use pink wards and your sweeper to clear out nunu's vision and try to farm as much as you can because you'll outscale nunu with items. Keep wards on dragon and baron so nunu doesn't sneak them with consume max.
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