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Very hard match up for twitch. Exhaust is a must to have a chance at killing in this match up (you or your support). Avoid all ins unless its up and you are at a health advantage.
Samira
Test if the enemy samira windwalls your W. This is key in this match up to winning, she can block many autos but if you can stack poison with your W its winnable.
Extremely hard if you die early. Play very cautious and safe. Once she dashes on you with her wind wall you cannot really fight back.
ALWAYS bait out wind wall before going all in. It has a long cool down and some samiras will throw it out carelessly. BE DILIGENT WITH THIS!
Its difficult but its winnable if you take the precautionary measures.
Draven
Early you will not be able to match his damage in extended trades at all. Once Draven gets vamp scepter the lane becomes very unwinnable, try to have your jungler get you a lead early and all in with your support. Once shieldbow is completed always keep track of this because if you E and do not account for the shieldbow, it could cost you your life.
Sett
Pretty difficult due to how the kits work. Sett wants to use his W at the same time that Twitch wants to use E. Just try to avoid getting 1 shotted by setts W and create distance.
Lulu
Lulu can pretty much negate a lot of your E damage with her R. That is assuming she actually uses it at the right time and doesn't get caught off guard. Polymorph can also ruin your entire opener so make sure that you have good space between you and lulu before you open near her.
Rengar
Rengar can see you in stealth with his R. Its pretty hard to position around him if he gets really fed. I would recommend taking exhaust to keep yourself safe.
Rek'Sai
Same thing as rengar, Reksai can see you in stealth and make it hard to get positioning in team fights if you are really trying to be unseen. I would recommend taking exhaust vs her as well.
Tryndamere
You cant kill him with your E and he can spin through your poison slow. Make sure that you are positioned near your support and people who can peel for you. Dealing with tryndamere cannot be done alone, its a team effort but it is doable.
Yasuo
DO NOT PRESS R WHEN HE HAS WIND WALL. Also do not throw your W into his wind wall its very important to try to make yasuo dash through your potent slow.
Braum
DO NOT PRESS R WHEN BRAUM HAS SHIELD AVAILABLE
Caitlyn
Early lane phase is annoying due to her range, just try to get as much cs as you can and do NOT miss exp to the best of your ability. The lane can be snowballed and you can kill caitlyn on repeat if you get a bit of help or hit a coordinated all in with your support.
Gwen
DO NOT PRESS R OR W WHEN GWEN HAS HER IMMUNE ABILITY AVAILABLE.
Nocturne
Try to open AFTER nocturn uses R. Otherwise you will be a sitting duck and you will die without putting out ANY damage because you cannot see anything.
Ashe
Early laning is a bit annoying with the Volley spam as well as her extended fight potential. Remember: twitch benefits the most from short trades EARLY. So do not extended fight vs ashe, you will lose.
Do not do a wild engage onto ashe shes a decent 1v1 champion. Make sure that you are in a good position to react to the ult.
Yuumi
She gives you an insane amount of Adaptive as well as the invisible R and Q from yuumi.
Top tier choice for ap twitch
Rakan
Can lock 2 people down very close to each other and line them up very well for R + W combo from twitch.
Lulu
Lulu is better for AD but still has good synergy for AP. Her abilities generally work very well with twitch even if the twitch is ap.
Swain
swain can W on top of your W to make it unavoidable without flashing. On top of that he can supplement damage early to help you score easy kills.
Thresh
Thresh is a great support champion in general.
Blitzcrank
Can help snowball early for you to become independent
Karma
Karma has a strong early game and can supplement damage for early kills. Karma has a strong kit that works well with twitch
Maokai
Strong engage champion
Shen
You can deliver shen when you are invisible right on top of the target
Nautilus
one of the strongest engage champions in the game
Bard
Bard needs to be playing amazing to make this synergy work. There is too many anti synergies with the two kits
Synergies
IdealStrongOkLowNone
Yuumi
She gives you an insane amount of Adaptive as well as the invisible R and Q from yuumi.
Top tier choice for ap twitch
Rakan
Can lock 2 people down very close to each other and line them up very well for R + W combo from twitch.
Lulu
Lulu is better for AD but still has good synergy for AP. Her abilities generally work very well with twitch even if the twitch is ap.
Swain
swain can W on top of your W to make it unavoidable without flashing. On top of that he can supplement damage early to help you score easy kills.
Thresh
Thresh is a great support champion in general.
Blitzcrank
Can help snowball early for you to become independent
Karma
Karma has a strong early game and can supplement damage for early kills. Karma has a strong kit that works well with twitch
Maokai
Strong engage champion
Shen
You can deliver shen when you are invisible right on top of the target
Nautilus
one of the strongest engage champions in the game
Bard
Bard needs to be playing amazing to make this synergy work. There is too many anti synergies with the two kits
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