Hello everyone,
This is my first guide and hope it will help you. And before we start, english is not my native language so sorry for the typos i may make.
I thought about on vayne and made lots of calculation and i found this is the best for me. I have enought survivability and enough damage to make enemies suffer in almost every phase of the game. If you want/like to play different play styles its up to you(You will hear this a lot :). As you know there is no true build or play style.

Little note about playstyle: It is based on repeated bursts.

For marks: 6x Greater Mark of Desolation+3x Greater Mark of Attack Damage works best for me but you can change them with Greater Mark of Attack Speed, Greater Mark of Desolation or Greater Mark of Attack Damage if you feel more comfortable.

For seals: Seals are 9x Greater Seal of Attack Speed to help you in early stages that you need them most. But if you say "I need survivability, because i hate being hit so hard" Then you can take Greater Seal of Armor or Greater Seal of Health." Yea this is and option too.

For glyphs: 9x Greater Glyph of Attack Speed is just workd great but there is tons of option. So feel free to change.

For Quintessences: 3x Greater Quintessence of Attack Damage

Note: Why 6x Greater Mark of Desolation and 3x Greater Mark of Attack Damage. This is a great mix that found after many calculation and i found it in a guide about Ezreal. They maximize your early damage output. For seals and glyphs, its about personal preference. If you like flat armor seals and magic resist per lvl glyphs(as i like them before), they are also works well but in this build you may want more attack speed in late stages.

Much word is not needed. 21 offence is must. 21-9-0 or 21-1-8 is an option.

Especially after last patch, 21-1-8 is looks cooler than 21-9-0 but your coice.

Heart of the guide =)
Doran's Blade is great for beginning. Healt, Life steal and AD is just great. But if you think that you take so much harass you can also take Vampiric Scepter first.

When you buy Sheen you will be in the laning phase and it works great with your Tumble, it makes your harass BEAST!!! The only thing you have to do is thumbling to the enemy and hitting but if you feel unsafe to Tumble to the enemies you can also use Condemn to push him/her back after you hit your Tumble+ Sheen mix.

Boots is need and the things goes alright, its no problem to spend 350 gold on it.

Vampiric Scepter adds to your sustainability. %3 Life steal from masteries and another %3 from Doran's Blade and now you have %18 Life steal =) Let them waste their mana pool to harass you HAHAHAA!!!

ArPen is just great and greater for us becuase we lost 15 Arpen from marks to take 10 Ad to maximize our early damage. Ad is makes us more dangerous. And Attack Speed is GREAT!!! that there will be a few Aspeed items we take.

Gangs will be more dangerous than before. You need a little more speed to make you feel more comfortable and, HEY! Here is the Berserker's Greaves. %90 of the matchs you will take it but if there is much CC and Caster i prefer to take Mercury's Threads rather than Berserker's Greaves.

We are in the mid game right now and need power. Trinity Force is there for you to make you so much lovelier than you were before. Everything increase a bit and and it creates wonders.

We are blowing death to the enemies and lets make this blow deadlier than before. Bloodthirster here. Great damage and life steal... Don't forget to stack it as quickly as possible.

Our damage rocks but attack speed suffers. Let's take Phantom Dancer.

With second Bloodthirster, we will kill them in seconds and our life steal keep us alive.

Tumble is must for early harass and great with Sheen. Silver Bolts are just maximize my attack + Tumble + attack combo and thats why i max it first. I'm just using Condemn to stun and don't think its damage helps me a lot more than Silver Bolts. It is personal preference to max Silver Bolts or Condemn secondly.

Exhaust and Flash is my personal favorites. Exhaust helps greatly in many circumstances as you know. While trying to catch an enemy that is fleeing,you can Tumble and Exhaust the target then take right position to stun and finish him right there. Or when you are fleeing you run into jungle and wait in bush(just agains 2 enemies) and Exhaust the one you will kill second and stun the other and kill him/her fast(If you can't, you will die most of the time). Than run or try to kill other champion.
Flash is known spell. I can just say if the second tip i gave you about Exhaust does not go well,you are in jungle so you can flash out.

You have a brain and you won't take Smite on Vayne so other spells are just your preference.

This is EXTREMLY IMPORTANT!!! If you are new. Make practise in custom game or Co-op. You must aim to take everything without pushing. In early phases, never push the minions just last hit them. Don't forget that you aim to take all minons so don't miss...

If enemy have extreme bursts and you are dying in the first salvo than wait till enemy casters use their skills. Than jump in the heat of the fight. If you can stun someone shoot. If the stunned one is a squish kill him/her. Than your first target is enemy squishies. Kill squishy casters or support than Ad carry(İf still alive, because your assassins or divers(like nocturne) are killing them before you aim them. If the enemy AD carry can't be killed by your team in a short time then you aim his/her after stunned target...

Note: Everything changes with teams. So use your BRAİN unless you are a troll.

- Be aware of the misses while you are walking.
- Be creative and use your thumble wise.
- Even if you have less healt than enemy(like he/she have %80 hp and you have %10), always remember that you have insane damage output and stunning them lets you have the kill.
- When you are playing a game you should focus. Focus wisely. When you are focused at last hit,you may not be aware of an incoming gang.
- Never rage, remember, this is just a game. Do what you have to.

All comments are welcome but please tell me the reason of your vote to help me improve myself or taste the sweetness of being helpful.