i chose boots of lucidity and yummo's ghost blade is because of the extreme cooldown reduction which helps u alot in team fights and in 1v1 battles.
i've used this build like hundreds of times and trust me it works like a charm and the best thing is that it makes u soo powerful compared to anyone in the game and it just makes the game so easy.

I chose my runes for maximum sustainability and power in mid and in early game and trust me they do help alot,trust me.
The runes will help alot when u start playing and i recomend these runes in a ranked match.

With Pantheon I took the masteries that suited him the best because he doesn't have alot of mana in early game and he doesn't have alot of damage too but with the masteries everything changes.

I have actually played in mid with Pantheon and he was extremely good. and very powerful in lane and ofcourse u can play with him bot but u have to play with a good partner because Pantheon is a squishy champion.

When it comes to pantheon and creeps he's a very good farmer because of his two important abilities which are:1.Spear shot 2.Heart-seeker strike.
u have to farm quickly and level up fatser than your opponents with Pantheon because he needs the gold and he needs to have as much damage as champions like: tryndamere, and he needs (HP) to keep up with tanks like: Amummu.

When u come to choose skill sequence u always have to start with spear shot because its causes the most damge,has the longest distance and has the lowest cooldown.
U must complete spear shot then Heart-seeker strike then Aegis of zeona because u need the damge from the 1st two to farm faster.

i hope u enjoyed and liked my Pantheon guide and I can assure u guys that it works a 100% because I've tried it many times and I showed it to one of my friends (Kekomm) and he used it and got a score of 35-7-13 on the first time he tried this build.