These Runes will give you the upper hand in the early aswell as in the late phase of the game.

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Electrocute is the meta rune allowing her to burst her enemies even more once you land your E. Cheap shot maximizes the damage output of your E+Q combo granting you extra true damage. Ghost Poro is a strong rune allowing you to have extra vision in map while also giving you extra force. Relentless hunter is a good rune for some extra moevement speed since she lacks mobility

Hexflash is a must rune for Zoe since it procs her W and giving her the active damage of it, also its good for fancy combos like Q+Hex+Q or even Q+Hex+Q+R .Last but not least Miniondematerializer is good for securing the minions with the balloons and pushing the lane faster for some roam

This Buid will grant you a sure late game victory

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Is the first and most essential item in her kit,Providing her with mana resource burst damage and cdr.I think its the most efficient first item for zoe and cannot be replaced by other item



Provides her with magic pen which allow her to pierce through mr making her Q even stronger



Morellonomicon is another core item which provides her with sustain and magic pen, making her less vonurable allowing her at the same damage to deal high dps even vs tanks



Rabadons maximizes her ability power making sure that her E Q R combo can one shot every carry.With rabadons and the previous items you will be strong enough to carry the game ,or at least deal some serious damage to your opponents



Zhonyas provides her with armor and the stasis effect which is very important since Zoe doesnt have much escaping tools, can help her stay alive in rough duels and teamfights



liandries torment VoidStaff and Liandries both allow her to shred even the tanky enemies depending on what they are building.If they stack mr rush VoidStaff , if they stack Hp rush Liandries.Now you are strong enough to Win!

This Spells can help you escape, engage or deal extra damage.

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Flash is the most common spell in almost every champion since it helps you chase ,escape or dodge a critical move from the enemy.I highly recommend it on Zoe since she lack moblity!


Ignite helps you do extra damage on lane and get some cleanup kills etc. also procs your W passive which deals significant extra damage securing almost every time the kill

Pros

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Zoe is a preetty strong Dps mage which has also the ability to shred tanks.She can be pretty usefull since she can oneshot every carry and deal damage from afar.Zoes early game is quite strong doing your E Q combo and procing the sleep effect.You have to look out for dropping spells which colcude from minions that hold baloons and/or from enemies that have recently use them, try to play aroudn them and use them in the most suitable timing.Try to play safe and deal damage with your Q R combo and look for easy kills with E Q R when they are below 50 hp. Zoe has a good waveclear with her Q allowing her to roam aswell, doing efficient ganks with her E through terrain (walls etc) assuring your team some lead.She has also high chances of stealing objectives such as barons and dragons.




Cons

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Zoe has low moblity and escape mechanics.So u have to be aware of the enemy assasins/bruiser who can actualyl shred her if missplayed.You have to keep your lane always warded for the above reason and be aware of the map and the movements of the enemy jungler she is pretty vanurable to ganks.Try not to autoattack the enemies when they sleep sicne they will wake up and prolly ruin your Q damage output (since it deals bonus true damage if the enemy is asleep)

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Hi, my league name is Elementalíst (was Victorious some time ago) and im a main mid laner diamond 5. I play league for 7 years but i play competitive for about a year.I play almost all the midlaners and i find Zoe one of the most enjoyable and fun to play with. Her kit allows her to do some pretty good plays and outsmart your opponent.She seems hard at start but with some games u can get the hang of it.She is pretty efficient in terms of teamcomp and ranked climbing since she has high dps and range which allow you to deal damage safely.The only problem is her low moblity which can be avoided if you have good map awarness and control of the map.I think this guide can help you learn the basic steps and give yoou some fre space to try your own combos and tricks with the champion, allowing you to experiment with your own pace and fit her in your own needs and skills.I think she is a pretty strong champ and can be pretty helpful if you understand her gameplay.
Hope you like my Guide :D